TLDR Heat Shock Proteins are important in the development of Polycystic Ovarian Syndrome and could be targets for new treatments.
Heat Shock Proteins (HSPs) play a significant role in the development of Polycystic Ovarian Syndrome (PCOS), a common endocrine disorder in women. HSPs, which maintain cellular proteostasis, have abnormal expression in PCOS, affecting the proliferation and apoptotic rates of ovarian cells and immunological processes. This dysregulation leads to an imbalance in proliferation/apoptosis that impacts follicle stage development, resulting in polycystic ovaries. HSPs are also associated with insulin resistance, chronic inflammation, and oxidative stress. The review suggests that modulating HSP activity could lead to new treatment strategies for PCOS. However, more research is needed to understand the detailed mechanisms of HSPs' impact on ovarian cells, their role in PCOS pathogenesis, and their potential therapeutic use.
19 citations,
March 2022 in “International Journal of Environmental Research and Public Health” Certain brain hormones and chemicals are linked to the development of Polycystic Ovary Syndrome.
129 citations,
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6 citations,
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54 citations,
November 2017 in “Scientific Reports” The study found that certain microRNAs are higher in the cells and lower in the fluid of women with a specific type of polycystic ovary syndrome, and one microRNA could potentially help diagnose the condition.
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September 2015 in “Expert Opinion on Therapeutic Targets” The conclusion is that while oral contraceptive pills are effective for PCOS-related high androgen levels, new treatments with fewer side effects are needed.
258 citations,
July 2016 in “Reproductive Biology and Endocrinology” The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.
35 citations,
May 2022 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism” Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.
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April 2021 in “Expert opinion on pharmacotherapy” Clascoterone is a new, effective, and safe acne treatment without systemic side effects.
