TLDR Avicennia marina extract can significantly promote hair growth in androgenic alopecia patients.
The study investigated the effects of Avicennia marina (AM) extract and its active component, avicequinone C (AC), on hair growth in androgenic alopecia (AGA) patients. The research demonstrated that AM and AC significantly inhibited the enzyme 5 alpha-reductase, which is involved in hair loss, by 92.46% and 75.34%, respectively. This inhibition led to increased expression of growth factors like HGF, KGF, and VEGF, promoting hair growth in the anagen phase. Additionally, AM and AC suppressed apoptosis pathways, delaying the catagen phase, and reduced BMP-4, further stimulating hair growth. Clinical testing on 47 subjects showed that a formulation containing 0.1% AM extract significantly increased hair growth over 4 months without causing irritation. These findings supported the potential of AM extract as a treatment for AGA.
December 2021 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Topical finasteride is promising for hair loss with minimal side effects but needs more research and approval.
6 citations,
April 2016 in “PubMed” The review found that women using hair loss drugs like finasteride and dutasteride rarely reported sexual side effects.
72 citations,
January 2004 in “Dermatology” Finasteride can slow hair loss and promote growth in postmenopausal women.
92 citations,
October 2002 in “Journal of The American Academy of Dermatology” Finasteride improves hair loss in women with hyperandrogenism.
10 citations,
June 2001 in “PubMed” Finasteride is effective in growing hair and stopping hair loss in men with mild to moderate alopecia.
65 citations,
October 1999 in “Journal of The American Academy of Dermatology” Finasteride effectively reduces hair loss by decreasing androgen levels.
187 citations,
June 1999 in “Journal of The American Academy of Dermatology” Finasteride effectively treats frontal hair loss with few side effects.
581 citations,
October 1998 in “Journal of The American Academy of Dermatology” Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.
