PSAT1 Regulates Hair Follicle Growth and Stem Cell Behavior in Cashmere Goats

    April 2025 in “ BMC Veterinary Research ”
    Xiaoyu Han, Jia‐Ning Liu, Nina Sun, Y Zhang, Hong Bai, Weiguo Song, Xiao Hu, Hao Liang, Miao Xiong, Yang He, Dongjun Liu, Xudong Guo
    TLDR PSAT1 is key for hair growth and stem cell function in cashmere goats.
    The study explores the role of PSAT1 in hair follicle growth and stem cell behavior in cashmere goats, revealing that PSAT1 expression is higher during the anagen phase and primarily located in the bulge region of secondary hair follicle stem cells (SHFSCs). Overexpression of PSAT1 inhibits SHFSC proliferation, induces cell cycle arrest, and promotes apoptosis, while knockdown enhances proliferation and reduces apoptosis. PSAT1 also negatively impacts SHFSC migration and wound healing. Transcriptomic analysis identified 2,799 differentially expressed genes, affecting pathways like Wnt/β-catenin, MAPK, and TGF-β. These findings suggest PSAT1 as a key regulator of hair follicle development, with potential implications for improving cashmere quality.
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