The Abnormal Skin Structure of Newborn Wistar Rats Maternally Treated with Aspartame: Histological and Immunohistochemical Study

May 2016 in “ Research opinions in animal & veterinary sciences ”

Abd El-Fattah, B. M. El-Beltagy, Heba A. El-Ghawet

aspartame epidermis dermis hair follicles hypertrophied cells cell damage apoptosis angiogenesis Caspase-3 P53 VEGF Caspase-7 CK17 flow cytometric analysis skin cell death blood vessel formation

TLDR Maternal aspartame consumption during pregnancy leads to skin damage and higher apoptosis in newborn rat offspring.

The study investigated the effects of aspartame, an artificial sweetener, on the skin structure of newborn Wistar rats whose mothers were treated with aspartame during pregnancy. Twelve pregnant female rats were divided into two groups: a control group given saline solution and an experimental group given 40mg of aspartame/kg body weight from the 4th day of pregnancy until birth. The results showed that the skin of aspartame-treated neonatal rats had significantly thinner epidermis and dermis, shallower hair follicles, hypertrophied cells, and signs of cell damage compared to the control group. Immunohistochemical analysis revealed increased expression of apoptosis and angiogenesis markers (Caspase-3, P53, VEGF) and decreased expression of Caspase-7 and CK17 in the aspartame group. Flow cytometric analysis showed a significant increase in apoptotic cells. The study concluded that maternal consumption of aspartame during gestation caused notable histological damage and increased apoptosis risk in the skin of their offspring.

View this study on roavs.com →

Discuss this study in the Community →

Similar Research

5 / 668 results

research Cannabinoid Compounds as a Pharmacotherapeutic Option for the Treatment of Non-Cancer Skin Diseases

3 citations, December 2022 in “Cells”

Cannabinoids like CBD and THC may help treat non-cancer skin diseases, but more research is needed.

research The Role of Integrin AlphaVbeta6 in Impaired Wound Healing and Hair Follicle Regeneration

January 2010

Integrin alphavbeta6 is important for wound healing and hair growth, and blocking it may improve these processes.

research Obstetric Dermatology

January 2009 in “Springer eBooks”

The document concludes that managing skin conditions during pregnancy is important and requires specialized care.

research Clinical Efficacy of Silk Sericin Dressing with Collagen for Split-Thickness Skin Graft Donor Site Treatment

January 2021

Silk sericin dressing with collagen heals wounds faster and improves scar quality better than Bactigras.

research Antigen Presenting Cells in the Skin of a Patient with Hair Loss and Systemic Lupus Erythematosus

9 citations, September 2009 in “PubMed”

Antigen presenting cells around hair follicles are crucial in SLE-related hair loss.

The Abnormal Skin Structure of Newborn Wistar Rats Maternally Treated with Aspartame: Histological and Immunohistochemical Study

Related Community Posts Join

community How is it that golden era bodybuilders kept their hair while blasting gear while in the modern era most are bald? I’m convinced there’s something in our food and water causing MPB to speed up

community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2

community Why balding gets worse in every generation?

community Parents found my finasteride stash and are forcing me to dispose all of it