286 citations,
June 2012 in “Nature Immunology” Hair follicles help attract immune cells to the skin during stress.
91 citations,
January 2010 in “Journal of Allergy and Clinical Immunology” NK cells play a role in skin diseases like eczema and psoriasis.
8 citations,
May 2020 in “Arthritis research & therapy” DHT inhibition may increase spinal bone growth in ankylosing spondylitis.
Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.
Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.
January 2023 in “Discovery immunology” T cells and bacteria in the gut and skin help maintain health and protect against disease.
October 2007 in “Journal of Investigative Dermatology” The meeting highlighted the genetic basis of female pattern hair loss and various skin health insights.
147 citations,
November 2020 in “International Journal of Molecular Sciences” Keratinocytes help heal skin wounds by interacting with immune cells and producing substances that kill pathogens.
129 citations,
May 2015 in “Cell Stem Cell” Different types of stem cells exist within individual skin layers, and they can adapt to damage, transplantation, or tumor growth. These cells are regulated by their environment and genetic factors. Tumor growth is driven by expanding, genetically altered cells, not long-lived mutant stem cells. There's evidence of cancer stem cells in skin tumors. Other cells, bacteria, and genetic factors help maintain balance and contribute to disease progression. A method for growing mini organs from single cells has been developed.
102 citations,
April 2014 in “PloS one” Wharton’s Jelly stem cells from the umbilical cord improve skin healing and hair growth without scarring.
60 citations,
September 2015 in “Expert Review of Clinical Immunology” Lymphocytes, especially CD8+ T cells, play a key role in causing alopecia areata, and targeting them may lead to new treatments.
53 citations,
August 2019 in “American journal of human genetics” FOXN1 gene variants cause low T cells and immune issues from birth.
40 citations,
March 2019 in “Nature Communications” CRAC channels are crucial for the development and function of specialized immune cells, preventing severe inflammation and autoimmune diseases.
39 citations,
April 2019 in “The journal of immunology/The Journal of immunology” Malt1 protease is essential for regulatory T cell function and could be targeted to boost antitumor immunity.
31 citations,
August 2015 in “Stem Cells Translational Medicine” Human skin can provide stem cells for tissue repair and regeneration, but there are challenges in obtaining and growing these cells safely.
25 citations,
August 2007 in “Molecular Therapy” Researchers found a safe and effective way to pick genetically modified skin cells with high growth potential using CD24.
21 citations,
November 2017 in “Scientific Reports” Different human hair follicle stem cells grow at different rates and respond differently to a baldness-related compound.
17 citations,
February 2016 in “Experimental Dermatology” SFRP2 boosts Wnt3a/β-catenin signals in hair growth cells, with stronger effects in beard cells than scalp cells.
15 citations,
July 2021 in “Bosnian Journal of Basic Medical Sciences” Stem cell therapy is promising for treating various health conditions, but more research is needed to understand its full potential and address challenges.
9 citations,
November 2012 in “Biomolecules & therapeutics” A compound from brown algae boosts the production of a certain inflammatory substance in skin cells.
9 citations,
September 2009 in “PubMed” Antigen presenting cells around hair follicles are crucial in SLE-related hair loss.
3 citations,
June 2023 in “MedComm” Stem cells and their exosomes show promise for repairing tissues and healing wounds when delivered effectively, but more research is needed on their tracking and optimal use.
2 citations,
January 2017 in “AIMS cell and tissue engineering” Mesenchymal stem cells show promise for treating various skin conditions and may help regenerate hair.
1 citations,
January 2023 in “International Journal of Molecular Sciences” Understanding how Regulatory T Cells work could help create treatments for certain skin diseases and cancers.
1 citations,
July 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” Keratin gene expression helps understand different types of skin cells and their development, and should be used carefully as biological markers.
1 citations,
June 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” Fetal skin has unique immune cells different from adult skin.
February 2024 in “Skin research and technology” The research suggests that immune cells and a specific type of cell death called ferroptosis are involved in Frontal fibrosis alopecia.
July 2023 in “Stem Cells Translational Medicine” Mesenchymal Stem/Stromal Cells (MSCs) help in wound healing and tissue regeneration, but can also contribute to tumor growth. They show promise in treating chronic wounds and certain burns, but their full healing mechanisms and potential challenges need further exploration.
254 citations,
January 2012 in “Nature Reviews Molecular Cell Biology” Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.
179 citations,
July 2016 in “Nature Reviews Molecular Cell Biology” Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.