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The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

Scientists at the University of Michigan Medical School successfully created a special compound that can be used to improve imaging of prostate cancer.

Researchers developed reliable models to predict how well certain compounds bind to androgen receptors, emphasizing the importance of atomic electronegativity.

New treatments for enlarged prostate are being developed to be more effective and have fewer side effects.

Scientists created iodinated arylhydantoins and arylthiohydantoins that could potentially be used for imaging prostate cancer. Some versions with specific side-chains showed high potential for this use.

Antiandrogens like flutamide are effective in treating conditions like prostate cancer and hair loss, but there's a need for more potent versions. Understanding their structure can help develop better treatments.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

Excess androgens may cause PCOS, not just be a symptom.

Finasteride worsens heart damage from nandrolone decanoate but protects against cell damage.

Hormone therapy for prostate cancer can increase heart risks, especially in men with heart conditions.

Guava leaf extract may help treat hair loss and protect cells by blocking certain genes and fighting damaging molecules.

Certain changes to the B-ring of androgen receptor ligands can increase their effectiveness for potential treatments of muscle and bone conditions.

Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Common latent viruses might contribute to male-pattern baldness by disrupting cell processes that normally suppress hair loss-related proteins.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.

New treatments for prostate cancer are less toxic and show promise, but more research is needed to enhance their effectiveness and reduce side effects.

Analog 23 is a promising compound for prostate cancer treatment.

Scutellaria baicalensis extract and baicalin may help prevent hair loss.

Understanding how androgens and their receptors work can lead to improved treatments for skin diseases.

Selective Androgen Receptor Modulators (SARMs) are drugs that can control the effects of androgens in different tissues, potentially having fewer side effects and promising for treating various conditions.

Blocking the androgen receptor in skin cells reduces their growth response to male hormones, suggesting a possible treatment for skin conditions linked to androgens.

A compound made by Pfizer can potentially stimulate hair growth and reduce oil production, making it a good candidate for topical use.

Fluridil promotes hair growth safely and effectively for androgenetic alopecia.

A new topical solution safely reduces hair shedding by 38% on average by tightening a muscle in the scalp.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.