Chapter 17: Selective Androgen Receptor Modulators (SARMs)

    January 2001 in “ Annual Reports in Medicinal Chemistry ”
    Lin Zhi, Esther A. Martinborough
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    TLDR Selective Androgen Receptor Modulators (SARMs) are drugs that can control the effects of androgens in different tissues, potentially having fewer side effects and promising for treating various conditions.
    The document from 22 years ago discussed Selective Androgen Receptor Modulators (SARMs), drugs that can selectively stimulate or block the effects of androgens in different tissues. The authors, Lin Zhi and Esther Martinborough, explained that testosterone (T) is a non-tissue-selective androgen with activities in both anabolic (bone and muscular) and androgenic (reproductive) target tissues. The indiscriminate activity of T led to the development of SARMs, which can separate these activities and potentially have fewer side effects. The authors also discussed the potential therapeutic uses of SARMs, such as treating osteopenia or osteoporosis in elderly men. They also covered the effects of androgens on bone and muscle, behavior, cognitive ability, prostate growth, hair growth, skin health, and spermatogenesis. The document concluded that the development of SARMs was in a very early stage, but they held promise for treating a variety of conditions.
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