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This study found that exosomes from adipose mesenchymal stromal cells, particularly those carrying miR-122-5p, may enhance hair follicle regeneration in androgenic alopecia by targeting the TGF-β/SMAD3 axis.

This review found that existing studies on adipose tissue for scarring, wound healing, and hair growth show some positive outcomes, but the evidence is insufficient to change current dermatological practices.

This study examined aging hair follicle stem cells in mice and found that inflammation reduction in dermal white adipose tissue can stimulate regenerative behavior, highlighting its role in hair follicle aging.

This study concluded that serum Adiol-G levels generally parallel testosterone levels and, therefore, do not effectively serve as a marker of peripheral androgen excess in women with androgenic symptoms.

This review examines mesotherapy for local fat reduction, detailing its mechanisms, safety concerns, and the need for research toward FDA-approved uses, but reports no new clinical findings.

This study identified a comprehensive global landscape of stemness-related gene clusters in adipose-derived mesenchymal stem cells, revealing that stemness was highest in cells from young donors and lowest in those from elderly donors.

This study found that ACOD1 deficiency in dermal papilla cells promotes mitochondrial dysfunction and contributes to cellular senescence in androgenetic alopecia, suggesting ACOD1 as a potential therapeutic target and 4-octyl itaconate as a promising treatment option for AGA.

This study found that UVB irradiation alters skin stem cell niches leading to signs of photoaging, which may be reversed by adipose-derived stem cells through BMP4 pathway modulation and niche remodeling.

This study found that TGFβ signaling is essential for keeping sebocytes undifferentiated by reducing lipid-related gene expression, using a novel human sebocyte culture model.

In this randomized clinical trial, the authors reported that adipose-derived stem cell constituent extract topical solution increased hair density and thickness in patients with androgenetic alopecia over 16 weeks compared to placebo.

Fat-derived stem cell therapies can potentially increase hair growth and thickness in people with hair loss.

Fat-derived stem cell therapies can potentially increase hair growth and thickness in people with hair loss.

This study found that human follicular papilla cells in the scalp produce leptin and express functional leptin receptors, suggesting leptin's significant role in hair biology.

The researchers reported that adipose-derived stem cells from type 2 diabetic mice showed comparable therapeutic effects in wound healing to control cells, despite slightly reduced growth factor secretion and healing promotion.

This study found that treating patients with androgenetic alopecia using exosomes from adipose tissue stem cells over 24 weeks significantly increased hair density and patient satisfaction without severe adverse effects, suggesting a promising alternative treatment for hair loss.

This study observed that partial autotaxin deficiency in mice protects against diet-induced obesity and systemic insulin resistance, suggesting the ATX-LPA pathway negatively affects skeletal muscle insulin signaling and mitochondrial function during obesity.

This study found that women with PCOS had higher body fat and worse insulin resistance than non-PCOS women, with body composition influencing metabolic profiles independently of PCOS status.

This study identified increased expression of ACAA1 and its regulation by hsa-miR-1343-3p, linking androgenetic alopecia to lipid metabolism pathways, particularly through PPAR signaling, in scalp tissues.

This study found that cyproterone acetate significantly reduced both serum 3α-AdiolG levels and hirsutism scores in women with idiopathic hirsutism, PCOS, or 21-hydroxylase deficiency, suggesting its effectiveness in treating excessive hair growth.

This report describes the clinical and histopathological features of lipoid proteinosis in a brother and sister with lid lesions, highlighting the importance of recognizing such lesions for diagnosis.

This pilot study found that a high fat lard diet may protect against fibrosis and affect the hair follicle cycle in a mouse model of systemic sclerosis, unlike a high fat coconut oil diet.

In this case report, an 11-year-old girl was diagnosed with lipedematous scalp, a condition typically observed in adult women, based on clinical features and histopathological findings.

This study observed that exosomes from adipose mesenchymal stem cells overexpressing hepatocyte growth factor significantly improved liver function and reduced fibrosis in mice with experimentally induced liver injury.

This study found that normal human melanocytes can be protected from apoptosis through both PI 3-kinase/Akt-dependent and independent pathways, with insulin and TPA offering nearly complete protection.

This study found that paeonol-loaded liposomal gels demonstrated antioxidant effects and relieved inflammation in AD-like mice, suggesting potential benefits for treating atopic dermatitis.

This study found that dermal papilla-like tissue reconstructed using canine adipose-derived mesenchymal stem cells closely resembles actual canine dermal papilla cells in both morphology and molecular characteristics.

This study found that antroquinonol inhibited CD8+ T cell proliferation and reduced proinflammatory cytokine secretion in vitro, while also ameliorating H2O2-induced depigmentation and resisting reductions in hair follicle length, skin thickness, and tyrosinase expression in mice.

This study found that in overweight or obese women with PCOS, certain baseline subcutaneous adipose tissue genes significantly predicted weight loss response to a 4-month behavioral lifestyle intervention, with the gene GSTM5 as the strongest predictor.

This study found that adipose-derived mesenchymal stem cells from type 2 diabetes mice are slightly less effective than controls but offer similar therapeutic benefits for wound healing.

This review discusses the role of peroxisome proliferator-activated receptors and their agonists in dermatology but reports no new clinical results.