Autotaxin-LPA Signaling Contributes to Obesity-Induced Insulin Resistance in Muscle and Impairs Mitochondrial Metabolism

The study concluded that the autotaxin-lysophosphatidic acid (ATX-LPA) signaling pathway significantly contributed to obesity-induced insulin resistance and impaired mitochondrial metabolism in muscle tissue. Male mice with partial ATX deficiency showed protection against obesity, improved insulin signaling, and better mitochondrial function when fed a high-fat high-sucrose diet. These findings suggested that targeting the ATX-LPA pathway could be a potential therapeutic strategy for improving insulin sensitivity and mitochondrial health in individuals with obesity.