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research Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism

45 citations , August 2018 in “Journal of Lipid Research”

This study observed that partial autotaxin deficiency in mice protects against diet-induced obesity and systemic insulin resistance, suggesting the ATX-LPA pathway negatively affects skeletal muscle insulin signaling and mitochondrial function during obesity.

research Impact of a High-Fat High-Carbohydrate (HFHC) Diet at a Young Age on Steroid Hormone Hair Concentrations in Mice: A Comparison with a Control Diet and Nutraceutical Supplementation

November 2025 in “Life”

This study found that switching juvenile mice from a high-fat, high-carbohydrate diet to a control diet optimally reduced hormonal imbalances and weight, with nutraceuticals offering partial support.

research Food hypersensitivity-induced chronic gastrointestinal inflammation in a non-human primate model of diet-induced obesity

April 2019 in “PLOS ONE”

This study found that a high-fat diet in macaques led to severe gastrointestinal inflammation and chronic wasting, with more pronounced effects in females, highlighting the potential risks of certain dietary interventions in obesity models.

research The Effects of the Ethanol Extract of Allium Ascalonicum L. in High-Fat-High-Fructose-Induced Insulin Resistance Swiss-Webster Male Mice

May 2025 in “Journal of Experimental Pharmacology”

This study found that Allium ascalonicum L. extract may improve insulin resistance by increasing insulin tolerance test values and lowering blood glucose levels, though more research is needed to understand its effects on metabolic disorders.

research Cardiac and Renal SARS-CoV-2 Viral Entry Protein Regulation by Androgens and Diet: Implications for Polycystic Ovary Syndrome and COVID-19

3 citations , September 2021 in “International Journal of Molecular Sciences”

This study suggests that women with polycystic ovary syndrome may have an increased risk of COVID-19-related cardiac and renal complications, and that weight loss through lifestyle changes could help reduce these risks.

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community Study on Sugar Intake on Male Pattern Hair Loss

19 upvotes 3 years ago

Excessive sugar and high-fat diets are linked to male pattern hair loss, with sweet beverages being a significant factor. Moderation in diet is advised, as diet alone may not fully prevent hair loss due to other factors like DHT sensitivity.

community 22M High Estrogen after blood test

1 upvotes 7 months ago

A 22-year-old male with high estrogen levels is considering finasteride for hair loss but is concerned about potential side effects due to his hormone levels and family history of diabetes. Users suggest consulting a doctor, possibly an endocrinologist, and considering lifestyle changes like diet and exercise to address visceral fat and insulin resistance before starting treatment.

community High Estrogen and Test on Dut 5x a week

6 upvotes 1 year ago

A user experienced increased pimples and cysts after two years on dutasteride, possibly due to hormonal changes. Suggestions included seeing an endocrinologist, using supplements like boron and DIM, adjusting diet, and reducing body fat to manage side effects.

community Check your hormones before dropping Finasteride if you are getting symptoms

59 upvotes 1 month ago

High body fat can increase estrogen levels, leading to side effects when using finasteride. Reducing body fat and checking hormone levels can help manage these side effects.

community Anybody else experience a itchy inflamed scalp after eating high sugar or fast foods?

3 upvotes 2 years ago

Eating high sugar or fast foods can cause an itchy, inflamed scalp, especially in areas with hair thinning. Reducing sugar intake and consuming vitamin D3 and fatty fish may help alleviate symptoms.

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Experts

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SMP Specialist
Craig Bottomley-High
Studham, England, United Kingdom
13+ yrs

Clinics

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Hair Loss Treatments
K&KOKORO Fat Cooling & Hair Growth Promotion Salon TokorozawaTokorozawa · JP

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Craig Bottomley-High