Therapeutic Effect of Exosomes Derived from Hepatocyte-Growth-Factor-Overexpressing Adipose Mesenchymal Stem Cells on Liver Injury

    October 2023 in “ Folia Histochemica et Cytobiologica ”
    Liu-Shen-Yan Yu, Junchao Xue, Yanyan Wu, Hanyu Zhou
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    Studysummary This study observed that exosomes from adipose mesenchymal stem cells overexpressing hepatocyte growth factor significantly improved liver function and reduced fibrosis in mice with experimentally induced liver injury.
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    The study investigated the therapeutic effects of exosomes derived from hepatocyte-growth-factor-overexpressing adipose mesenchymal stem cells (ADMSCHGF-Exo) on liver injury in mice. The results demonstrated that ADMSCHGF-Exo had a hepatoprotective effect, as evidenced by the alleviation of hepatic fibrosis and the restoration of liver function in the experimental models. This suggests that ADMSCHGF-Exo could be a potential treatment for liver injury.
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