Exosomes Derived From Human Adipose-Derived Stem Cells Inhibit Lipogenesis Involving Hedgehog Signaling Pathway

    August 2021 in “ Frontiers in Bioengineering and Biotechnology ”
    Ziwan Ji, Zhongming Cai, Shuming Gu, Yucang He, Zikai Zhang, Tian Li, Qing Wei, Jingping Wang, Ke Chen, Liqun Li
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    Studysummary This study found that adipose-derived exosomes may inhibit adipogenesis and lipogenesis in adipose-derived stem cells by activating Hedgehog signaling, suggesting potential applications for improving wound healing in obesity. Our plain-language summary of this paper — not a Tressless recommendation.
    The study demonstrated that exosomes derived from human adipose-derived stem cells (ADEs) inhibited adipogenic differentiation and lipogenesis in adipose-derived stem cells (ADSCs) by activating the Hedgehog (Hh) signaling pathway. ADEs increased the expression of key Hh pathway genes and decreased the expression of the suppressor gene Ptc1, leading to reduced lipid accumulation and adipogenic differentiation, especially under high-fat conditions. This suggested that ADEs could potentially be used in regenerative medicine to modulate adipogenesis and improve conditions related to obesity, such as wound healing. However, further in vivo studies were needed to confirm these effects.
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