Exosomes Derived From Human Adipose-Derived Stem Cells Inhibit Lipogenesis Involving Hedgehog Signaling Pathway

August 2021 in “ Frontiers in Bioengineering and Biotechnology ”

Ziwan Ji, Zhongming Cai, Shuming Gu, Yucang He, Zikai Zhang, Tian Li, Qing Wei, Jingping Wang, Ke Chen, Liqun Li

exosomes human adipose-derived stem cells lipogenesis Hedgehog signaling pathway adipogenesis adipose-derived stem cells lipid accumulation

TLDR Exosomes from fat stem cells can reduce fat cell formation.

The study demonstrated that exosomes derived from human adipose-derived stem cells (ADEs) inhibited adipogenic differentiation and lipogenesis in adipose-derived stem cells (ADSCs) by activating the Hedgehog (Hh) signaling pathway. ADEs increased the expression of key Hh pathway genes and decreased the expression of the suppressor gene Ptc1, leading to reduced lipid accumulation and adipogenic differentiation, especially under high-fat conditions. This suggested that ADEs could potentially be used in regenerative medicine to modulate adipogenesis and improve conditions related to obesity, such as wound healing. However, further in vivo studies were needed to confirm these effects.

View this study on frontiersin.org →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

Up-To-Date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss

research Up-To-Date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss

30 citations , June 2017 in “Current stem cell research & therapy”

Adipose-derived stem cells (fat cells) show promise in treating hair loss in both men and women.

research Targeting Smoothened for Therapeutic Gain

105 citations , April 2014 in “Trends in Pharmacological Sciences”

Targeting the Smoothened receptor shows promise for treating certain cancers.

Similar Research

5 / 930 results

research The Potential Role of Exosomes in Aesthetic Plastic Surgery: A Review of Current Literature

June 2023 in “Plastic and Reconstructive Surgery – Global Open”

Exosomes may improve skin, scars, hair growth, and fat grafts in plastic surgery, but more research is needed.

research Obesity and Wound Healing: Focus on Mesenchymal Stem Cells

3 citations , March 2023 in “Life”

Obesity can worsen wound healing by negatively affecting the function of stem cells in fat tissue.

research Progress on Mitochondria and Hair Follicle Development in Androgenetic Alopecia: Relationships and Therapeutic Perspectives

February 2025 in “Stem Cell Research & Therapy”

Maintaining healthy mitochondria may help treat hair loss.

research Autophagy Dysfunction: The Kernel of Hair Loss?

May 2024 in “Clinical Cosmetic and Investigational Dermatology”

Manipulating cell cleanup processes could help treat hair loss.

research Dermal Adipose Tissue Secretes HGF to Promote Human Hair Growth and Pigmentation

29 citations , January 2021 in “Journal of Investigative Dermatology”

Fat under the skin releases HGF which helps hair grow and gain color.

Exosomes Derived From Human Adipose-Derived Stem Cells Inhibit Lipogenesis Involving Hedgehog Signaling Pathway

Research cited in this study

research Up-To-Date Clinical Trials of Hair Regeneration Using Conditioned Media of Adipose-Derived Stem Cells in Male and Female Pattern Hair Loss

research Targeting Smoothened for Therapeutic Gain

Related Community Posts Join

community My progress with various products and without oral fin or oral dut on 17 months

community Nice & pure PRP, 3 ml of this is going to the scalp.

community A New Therapeutic Channel to Come Soon: Hair Follicle Sugar Metabolism and Aldose Reductase

community Innovative hair loss treatment can restore 90% of lost hair

community Has anyone tried Exosomes from Musely or somewhere else?