Exosomes Derived From Human Adipose-Derived Stem Cells Inhibit Lipogenesis Involving Hedgehog Signaling Pathway

August 2021 in “ Frontiers in Bioengineering and Biotechnology ”

Ziwan Ji, Zhongming Cai, Shuming Gu, Yucang He, Zikai Zhang, Tian Li, Qing Wei, Jingping Wang, Ke Chen, Liqun Li

exosomes human adipose-derived stem cells lipogenesis Hedgehog signaling pathway adipogenesis adipose-derived stem cells lipid accumulation

TLDR Exosomes from fat stem cells can reduce fat cell formation.

The study investigated the role of exosomes derived from human adipose-derived stem cells (ADEs) in inhibiting adipogenesis and lipogenesis in adipose-derived stem cells (ADSCs) through the Hedgehog (Hh) signaling pathway. Researchers co-cultured ADSCs with ADEs and found that ADEs inhibited adipogenic differentiation and activated Hh signaling, particularly under high-fat conditions. The study concluded that while increased Hh signaling activation was necessary, it was not sufficient alone to inhibit adipogenic differentiation. ADEs effectively reduced lipid accumulation in ADSCs, suggesting potential clinical applications for reducing obesity's adverse effects on wound healing.

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