Human Bone Marrow Mesenchymal Stem Cells-Derived Exosomes Stimulate Cutaneous Wound Healing Mediated Through TGF-β/Smad Signaling Pathway

    April 2020 in “ Research Square (Research Square) ”
    Tiechao Jiang, Zhongyu Wang, Ji Sun
    TLDR Exosomes from stem cells help wounds heal faster by affecting specific cell signals.
    The study investigated the effects of human bone marrow mesenchymal stem cells-derived exosomes (hBM-MSCs-Ex) on cutaneous wound healing in rats. It was found that hBM-MSCs-Ex effectively promoted the growth of human keratinocytes and human dermal fibroblasts, accelerating wound healing. The mechanism involved the modulation of the TGF-β/Smad signaling pathway, with a down-regulation of TGF-β1, Smad2, Smad3, and Smad4, and an up-regulation of TGF-β3 and Smad7. These findings suggested that hBM-MSCs-Ex could be a promising cell-free therapeutic strategy for treating cutaneous wounds.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 15 results

      community Anyone Try Microneedling with Exosomes/AAPE?

      in Microneedling  2 upvotes 3 years ago
      User asks where to purchase exosomes/AAPE for microneedling hair loss treatment. Links to research on hair regeneration therapy, stem cell therapy, exosome therapy, and dermal exosomes provided.

      community Mesenchymal Stem Cell Therapy (Exosome) Before & After

      in Treatment  2 upvotes 1 year ago
      A user's father experienced hair regrowth and other health improvements after two IV exosome treatments. The user also had four rounds of exosome therapy, noting significant hair regrowth and relief from headaches, but no change in gray hair.

      community 1.5 Year Hair Restoration Journey - Stem Cells, PRP, Minoxidil, Topical Finasteride

      in Progress Pictures  26 upvotes 1 year ago
      A user shared their 1.5-year hair restoration journey, successfully using mesenchymal stem cell therapy, Platelet Rich Plasma (PRP) injections, and a topical compound of finasteride and minoxidil, avoiding a hair transplant and oral finasteride. They experienced significant hair regrowth, particularly crediting the stem cell therapy for quick initial results.

      community This guy claims stem cells fixed his balding

      in Is this regrowth?  301 upvotes 2 years ago
      A man who claimed to have regrown his hair using stem cell treatment, sparking a debate about its effectiveness and cost. Some users suggested he might be using other treatments or substances, while others shared their own experiences with stem cell therapy for hair loss.

    Similar Research

    5 / 1000+ results