This study reported that the HG3 formulation of a Ketoconazole anti-dandruff gel exhibited superior drug release and antifungal efficacy without causing skin irritation, compared to other formulations tested.
April 2005 in “The Journal of urology/The journal of urology” Dutasteride may help treat prostate cancer by causing cancer cells to shrink and die.
This review discusses various syndromes of severe insulin resistance, their biochemical and clinical features, and potential therapeutic options, but it reports no new clinical results.
December 2002 in “International Journal of Cosmetic Surgery and Aesthetic Dermatology” This study investigated a potential link between male pattern baldness and Pityrosporum group fungal contamination but found no significant statistical association.
August 1994 in “Drugs & Therapy Perspectives” The document concludes that H2-antagonists and proton pump inhibitors are highly effective for ulcers, eradicating Helicobacter pylori is important to prevent recurrence, and misoprostol helps with NSAID-related ulcers.
October 1993 in “Proceedings of The Nutrition Society” Dietary choices, especially fat type, can influence health.
August 1946 in “Journal of the American Medical Association” This abstract reports no new research findings and instead provides information about the JAMA website features and usage terms.
January 2022 in “المجلة العراقية للصيدلة” In this review, researchers examined the molecular pharmacology and effects of topical minoxidil, noting its potential to treat androgenetic alopecia by enhancing hair regrowth, while also discussing advanced formulation methods like nanoemulsion and nanocarrier systems to improve its delivery.
January 2021 in “Hair transplant forum international” Microneedling may help hair growth, but its pain and mixed results make its effectiveness unclear.
1533 citations
,
October 2008 in “Endocrine reviews” This research highlights that engineered mice lacking the vitamin D receptor show multiple health issues similar to human vitamin D deficiency, underscoring the widespread impacts of the vitamin D endocrine system.
441 citations
,
May 2008 in “British Journal of Pharmacology” This article reviews the potential clinical use of anabolic steroids in treating muscle loss from chronic diseases and aging and highlights both the benefits and risks of these substances in sports.
356 citations
,
March 2012 in “Trends in Plant Science” This review discusses the crosstalk between auxin and ethylene in seedling growth and development, emphasizing how ethylene modulates auxin's effects across different tissues.
321 citations
,
January 2012 in “Cell stem cell” This study identified TGF-β2 as a crucial signal in hair follicle stem cell regeneration, highlighting its role in counteracting BMP signaling to promote tissue regeneration.
305 citations
,
February 2007 in “Hormone and metabolic research” This review discusses the roles of androgens and estrogens in skin functions and disorders, and highlights the use of estrogen-progestin treatments and anti-androgens in managing hirsutism and acne, without reporting new results.
270 citations
,
March 2012 in “Dermatologic Surgery” This study found that autologous platelet-rich plasma increased hair growth potential by enhancing dermal papilla cell proliferation and stimulating key signaling pathways in both cell cultures and mice models.
263 citations
,
February 2011 in “Journal of Controlled Release” This study found that medium-sized particles (643 and 646 nm) penetrated deeper into porcine hair follicles in vitro than smaller or larger particles, suggesting size-selective targeting within follicular sites.
257 citations
,
July 2018 in “Obstetrics & Gynecology” This review discusses the various phenotypes and diagnostic challenges of polycystic ovary syndrome, highlighting its complex pathophysiology and associated health risks, and reports no new clinical results.
249 citations
,
November 2003 in “Clinical endocrinology” This review discusses the complex etiology of polycystic ovary syndrome (PCOS), highlighting its association with insulin resistance and hyperandrogenism, but reports no clinical findings; the authors suggest further investigation of the pathophysiological mechanisms.
193 citations
,
January 2015 in “International journal of trichology” This review examines hair cosmetics, including shampoos and conditioners, for their formulations and effects, but reports no new clinical findings; it emphasizes the importance of dermatologist knowledge in treating diverse hair conditions.
163 citations
,
March 2012 in “BMC biology” This forum article in BMC Biology discusses evolving views on the concept of the stem cell niche, highlighting varied mechanisms and the need for better understanding of the niche's roles and functions.
149 citations
,
March 2004 in “Journal of Dermatological Science” This study found that minoxidil stimulates hair follicle growth by promoting dermal papilla cell survival and activating ERK and Akt pathways, which leads to increased proliferation and reduced cell death.
135 citations
,
March 2000 in “Journal of Biological Chemistry” This review discusses the roles of the Agouti and Agouti-related proteins in pigmentation and energy regulation and reports no new experimental findings.
129 citations
,
February 2006 in “Andrology” This article reviews considerations and guidelines for testosterone therapy in older men with low testosterone levels but does not provide new clinical results, emphasizing the need for ongoing evaluation and careful management, particularly regarding risks related to prostate and cardiovascular health.
128 citations
,
March 2006 in “American Journal of Pathology” The study found that prolactin expressed in human scalp hair follicles acts as an autocrine modulator, inhibiting hair growth and promoting hair follicle regression, which may contribute to hair loss in hyper-prolactinemia patients.
121 citations
,
May 2009 in “Journal of Ethnopharmacology” This study found that the methanol extract of Eclipta alba showed dose-dependent hair growth promoting activity in pigmented C57/BL6 mice by influencing the transition from the telogen to anagen phase.
111 citations
,
April 2023 in “Ultrasonics Sonochemistry” This review discusses the extraction, purification, and biological activities of maidenhairtree polysaccharides, emphasizing the higher efficiency of ultrasound-assisted extraction, but it reports no new clinical results.
111 citations
,
June 2002 in “The EMBO Journal” This study found that overexpression of Smad7 in transgenic mice led to severe alterations in multiple epithelial tissues, resulting in early death after birth.
109 citations
,
January 1997 in “Journal of Experimental Botany” This paper discusses the cellular and molecular processes involved in root hair growth in higher plants, focusing on cytological phenomena and the effects of growth regulators and mutations, but reports no new experimental findings.
108 citations
,
September 2002 in “The Journal of clinical investigation/The journal of clinical investigation” This study found that reducing testosterone levels in male mice accelerates wound healing and decreases inflammation, suggesting a potential therapeutic target for improving wound repair in elderly males.
100 citations
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November 2017 in “EMBO Reports” This review discusses the roles of metabolism, reactive oxygen species, intracellular pH, and cell morphology in influencing cell fate decisions during stem cell differentiation but reports no new experimental results.