Factors to Consider When Selecting Antiulcer Drugs for a Formulary
August 1994
in “
Drugs & Therapy Perspectives
”
TLDR The document concludes that H2-antagonists and proton pump inhibitors are highly effective for ulcers, eradicating Helicobacter pylori is important to prevent recurrence, and misoprostol helps with NSAID-related ulcers.
The document from 1994 discussed the factors to consider when selecting antiulcer drugs for a formulary, including their mechanism of action, efficacy, tolerability, drug interactions, administration, costs, and pharmacoeconomic studies. It highlighted the high efficacy and tolerability of H2-antagonists and proton pump inhibitors, with omeprazole and lansoprazole having healing rates of over 90% for ulcers. The document emphasized the importance of eradicating Helicobacter pylori to reduce ulcer recurrence, recommending triple therapy despite concerns about metronidazole resistance, and suggested that H. pylori eradication might be more cost-effective than long-term antisecretory therapy. Additionally, it addressed the management of drug-induced hair loss and other hair conditions, recommending dosage adjustments, drug discontinuation, and treatments like minoxidil. Misoprostol was mentioned as effective for preventing and treating NSAID-associated ulcers, particularly in high-risk patients.
