September 2025 in “Cosmetics” This study found that using a pharmacogenetic panel with 26 SNPs can improve treatment outcomes for androgenetic alopecia, as overall response rates to minoxidil, finasteride, and dutasteride were high, and specific genetic markers predicted poor responses to these drugs.
April 2025 in “International Journal of Medical Science and Diagnosis Research” This study developed a polyherbal shampoo using herbal extracts as an alternative to chemical-based shampoos, aiming to provide a safer and more effective hair care option.
January 2025 in “Molecules” In this review, the authors discuss caffeine's potential mechanisms and benefits as a hair loss treatment, noting its possible effectiveness and safety, though they caution that existing studies often have significant design flaws.
November 2024 in “Journal of Investigative Dermatology” Androgens reduce hair growth by affecting cell differentiation and blood vessel formation.
February 2024 in “PloS one” This study found that certain nutraceuticals did not interfere with tamoxifen's inhibition of estrogen in breast cancer cells and may enhance its effects, suggesting potential as an adjuvant therapy for hair loss in patients undergoing endocrine therapy.
June 2023 in “Current Issues in Molecular Biology” In this study, the alcoholic extract DN106212 from Centipeda minima was shown to be more effective in promoting hair growth in C57BL/6 mice compared to dimethyl sulfoxide and tofacitinib, suggesting its potential as a natural hair growth agent.
February 2022 in “Research Square (Research Square)” In this cell-based study, researchers found that certain nutraceuticals combined with tamoxifen may influence estrogen receptor expression, potentially offering a protective effect and promoting hair growth during breast cancer therapy.
December 2021 in “Research Square (Research Square)” This study suggests that certain nutraceuticals may enhance the inhibitory effects of tamoxifen on estrogen in breast cancer cells and potentially offer protective benefits for hair growth in patients undergoing endocrine therapy.
December 2021 in “Journal of Investigative Dermatology” This study reports that inhibition of Wnt/β-catenin signaling disrupts hemidesmosome organization in keratinocytes by altering the localization of components like plectin and collagen XVII.
August 2021 in “The journal of investigative dermatology/Journal of investigative dermatology” This study explored the effects of various nutraceutical ingredients on breast cancer cell lines but found no conclusive information regarding their interaction with tamoxifen therapy.
December 2020 in “Current Sexual Health Reports” This review discusses the role of neurosteroids and androgens throughout different life stages, noting the potential disruptions caused by 5α-reductase inhibitors like finasteride, but no new clinical results are reported.
May 2020 in “JAAD case reports” This source describes a previous case report that combined anthralin and calcipotriene to treat alopecia areata, showing promising results, but highlights that further research is needed to understand the mechanisms and potential benefits of this combination therapy.
In this study, deer hair follicles were shown to be an effective in vitro bioassay model, demonstrating that K(ATP) channel modulators directly influence hair follicle growth through specific channel types.
November 2003 in “Journal of Neurochemistry” This study suggests that the neurosteroid allopregnanolone may play a crucial role in how ethanol affects neurons related to alcohol addiction vulnerability.
June 1996 in “Journal of Dermatological Science” Two new compounds were found that could promote hair growth as well or better than minoxidil.
March 2023 in “Natural product sciences” This study demonstrated that Celtis choseniana Nakai may help alleviate androgenic alopecia by enhancing hair regrowth and activating Wnt/β-catenin signaling in both a mouse model and cultured human cells.
33 citations
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January 2006 in “Journal of Dermatological Science” This article reviews the molecular interactions involved in hair follicle cycling and highlights the role of dermal papilla cells, but it presents no new research findings.
1 citations
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August 2022 in “Molecules” This study found that components in the kernel of Prunus mira Koehne, such as vitamin E and β-sitosterol, may promote hair growth in mice, possibly involving the Wnt/β-catenin signaling pathway.
137 citations
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December 2007 in “Journal of bone and mineral research” This study suggests that 1,25-dihydroxyvitamin D(3) and fibroblast growth factor 23 form a crucial axis in regulating phosphate balance, akin to its role in calcium regulation, and explores novel VDR interactions including with curcumin.
70 citations
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January 2000 in “Drug Development Research” The researchers reported that a novel family of butyric acid prodrugs, including AN-9 and AN-10, showed potential for anticancer activity, hemoglobin expression induction, and hair follicle protection, with AN-9 in phase II trials.
65 citations
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May 2006 in “Journal of Investigative Dermatology” This study found that dexamethasone significantly reduced ERα mRNA levels and increased aromatase mRNA and activity in cultured human hair follicle dermal papilla cells, suggesting a glucocorticoid-dependent mechanism for estradiol action.
35 citations
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March 2005 in “Journal of Investigative Dermatology” In this in vitro study, minoxidil, diazoxide, and the novel compound NNC 55-0118 increased hair follicle growth, supporting deer follicles as a viable bioassay for ATP-sensitive potassium channel modulators.
20 citations
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November 2008 This chapter discusses the production, metabolism, and mechanism of action of Vitamin D, including its role in calcium and phosphate metabolism and its function in the epidermis and hair follicles, without presenting new research findings.
17 citations
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September 2022 in “Biomaterials Research” This study found that the film-trigger applicator system enhanced drug delivery efficiency and skin penetration of dissolving microneedles compared to traditional patch systems in both lab and animal models.
16 citations
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November 2019 in “Dermatologic Surgery” This review examines the current evidence for platelet-rich plasma in dermatology, finding favorable outcomes particularly for androgenetic alopecia, but highlights the need for more rigorous clinical trials and standardized protocols.
12 citations
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June 2017 in “Cell Cycle” This study observed that 5% minoxidil topical foam alters gene expression and signaling pathways in the scalp, providing insights into its mechanism of action in men with androgenetic alopecia.
2 citations
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August 2024 in “Heliyon” This study concluded that Metformin may be suitable for prophylaxis or mild COVID-19, while a combination of Oseltamivir, Tamoxifen, and Dexamethasone could benefit moderate to severe cases, highlighting the need for more trials on other drug candidates.
2 citations
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June 2023 in “Food science & nutrition” This review summarizes evidence that apple and apple products may offer protective effects against various health issues, including cardiovascular diseases, cancer, mild cognitive impairment, and skin conditions, due to their phytochemical content and mechanisms like anti-inflammatory and antioxidant actions.
1 citations
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April 2023 in “African Scientific Reports” This review summarizes the biological process of melanogenesis and evaluates natural skin-whitening treatments based on their mechanisms affecting melanin production, aiming to inform on the effects and awareness of skin-bleaching creams.
April 2026 in “Industrial & Engineering Chemistry Research” This study showed that keratinase pretreatment effectively reduces the time for enzymatic unhairing in bovine hides by opening channels for faster penetration, which shortens the process by over 50% and enhances leather quality.