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research Development and Physicochemical Evaluation of a Polyherbal Dual-Action Shampoo for Hair Coloring and Conditioning
This study explains the formulation and evaluation of a natural polyherbal shampoo, which effectively colors hair and provides conditioning without the dermal and systemic toxicity risks of synthetic dyes, offering an effective alternative to conventional products.
research Azelaic Acid in Dermatology: A Review of Its Mechanism of Action
This study highlights that azelaic acid, initially recognized for skin hypopigmentation, shows potential in treating various skin conditions due to its complex mechanisms, even though these are not yet fully understood, indicating a need for further research.
research Dissolving microneedle patch loading dutasteride microspheres for the long-acting treatment of androgenetic alopecia
A dissolving microneedle patch with dutasteride offers effective, long-lasting hair loss treatment with fewer side effects.
research Glutamic acid-loaded separable microneedle composite for long-acting hair regeneration treatment
This study reported that in animal studies of androgenetic alopecia, a biodegradable microneedle patch releasing glutamic acid promoted hair regeneration more effectively than daily minoxidil, with higher hair follicle counts and less frequent dosing, showing the potential for clinical application.
research Iron Deficiency Anemia Pruritus: A Review with Proposed Mechanisms of Action
This review supports iron deficiency anemia as a valid cause of chronic generalized pruritus and suggests potential mechanisms by which iron deficiency may lead to pruritus, but reports no new clinical results.
research Small Molecules Accelerate Skin Wound Healing: Shikonin Efficacy and Mechanism of Action in Mice
In this study, researchers observed that shikonin promotes wound healing in a mouse burn model by enhancing skin cell proliferation and fibroblast activity through the PI3K/AKT signaling pathway, suggesting its potential as a therapeutic treatment for skin injuries.
research The multiple uses of azelaic acid in dermatology: mechanism of action, preparations, and potential therapeutic applications
This review provides an overview of azelaic acid's dermatological uses, mechanisms, and its potential in skin cancer treatment, but reports no new clinical results.
research Experimental study of Karaviradya taila for its Loma Shatana action
This study observed that karaviradya taila application on albino rats reduced hair growth by affecting hair follicles compared to a control group.
research 397 Predictive modeling of drug response and mechanism of action in alopecia areata clinical trials
In this study, distinct molecular mechanisms of action were identified for three drugs used in alopecia areata clinical trials, providing insights for precision medicine and treatment selection.
research Dissolving Microneedle Patch Integrated with Microspheres for Long-Acting Hair Regrowth Therapy
This study reports that a water-soluble microneedle patch with minoxidil-loaded microspheres showed similar or better hair regeneration effects in mice with less frequent application compared to daily topical minoxidil.
research Dissecting Hierarchies between Light, Sugar and Auxin Action Underpinning Root and Root Hair Growth
This study found that light and sucrose have opposing effects on root length but collectively enhance root hair emergence and elongation in plant roots.
research Intracrine androgen biosynthesis, metabolism and action revisited
This article discusses the role of androgens in metabolic and reproductive health and reports no new experimental results; the focus is on androgen receptor activation by testosterone and 5α-dihydrotestosterone.
research Topical and nutricosmetic products for healthy hair and dermal antiaging using “dual‐acting” (2 for 1) plant‐based peptides, hormones, and cannabinoids
This review discusses plant-based alternatives to retinoids for dermal antiaging and hair health, highlighting roles for cytokinins and phytoestrogens and reports no new results.
research Network pharmacology and molecular docking analysis on potential molecular targets and mechanism of action of BRAF inhibitors for application in wound healing
This study suggests that BRAF inhibitors, particularly Encorafenib and Dabrafenib, may have potential applications in wound healing by targeting specific proteins involved in the healing process in murine models.
research Minoxidil toxicosis in cats and dogs: A scoping review and call to action
This scoping review investigates cases of toxic minoxidil exposure in cats and dogs, detailing their clinical presentations, management strategies, and outcomes, without reporting specific results.
research Intoxication par le minoxidil, principe actif d’une lotion capillaire. À propos d’un cas
This case report describes a young girl who experienced vasoplegic shock and prolonged tachycardia after ingesting hair lotion containing minoxidil, highlighting the need for extended monitoring due to potential persistent hemodynamic issues.
research Alteration of serum and tissue tumor necrosis factor alpha levels: A possible mechanism of action of oral pulse steroids in the treatment of alopecia areata
This study found that oral pulse steroids significantly reduced serum and tissue levels of TNF-α in patients with alopecia areata, correlating with clinical improvement.
research Cytokine-Targeting Biologic Therapies for Alopecia Areata: A Comprehensive Review of Mechanism of Action, Clinical Efficacy, and Adverse Events
This study reviewed clinical trials and reports on cytokine-targeting biologics for alopecia areata, finding Dupilumab and Ustekinumab showed strong efficacy, while other biologics had limited success or worsened the condition. Further research is needed to optimize biologic therapies for AA.
research Formulation and Evaluation of Polyherbal Shampoo to Promote Hair Growth and Provide Antidandruff Action
This study reports the formulation and evaluation of an herbal shampoo, "Herbello", aimed at improving antidandruff activity using various natural ingredients.
research Discovery of a sol–gel reinforcing the strength of hair structure: mechanisms of action and macroscopic effects on the hair
This study found that 3-aminopropyltriethoxysilane penetrates hair fibers and improves the mechanical resistance of dry hair, addressing the needs for increased body in fine hair.
research The Role of Cannabinoids in the Treatment of Skin Diseases: A Review of Mechanisms of Action and Clinical Evidence
This study suggests that cannabinoids, especially CBD, show promise as potential treatments for various inflammatory, infectious, and autoimmune skin diseases, with ongoing research needed to confirm clinical efficacy and safety.
research Mechanistic Underlying Anti-diabetic Potential of Eclipta alba Flavonoids against Aldose Reductase Inhibitory Action
This study used in-silico molecular docking to evaluate the antidiabetic potential of Eclipta alba leaf flavonoids, finding that compounds like apigenin, syringic acid, and vanillic acid effectively bind to the target protein aldose reductase, suggesting a promising inhibitory action.
research ZmSPL10, ZmSPL14 and ZmSPL26 act together to promote stigmatic papilla formation in maize through regulating auxin signaling and ZmWOX3A expression
In this study, researchers identified that three homologous genes—ZmSPL10, ZmSPL14, and ZmSPL26—are crucial for the development of stigmatic papilla in maize, with triple knockout mutants lacking these genes showing almost no stigmatic papilla and significantly reduced kernel setting.
research Anabolic-androgenic steroids. Mechanism of action and clinical effects
This study provides a comprehensive analysis of anabolic-androgenic steroids, reporting that their use enhances muscle mass but is associated with significant health issues including cardiac muscle hypertrophy, liver disease, and changes in gender characteristics, emphasizing the need for patient awareness of these risks.
research Mitigating GLP-1–Related Dermatologic Adverse Effects through Methylene Blue’s Antioxidant Action
This review discusses how glucagon-like peptide-1 receptor agonists, used for type 2 diabetes and obesity, may cause skin aging and hair loss, and explores methylene blue as a potential protective treatment.
research 164 Unlocking the power of platelet rich plasma (PRP) in dermatology: mechanism of action, clinical efficacy, and new applications
This review evaluates the clinical efficacy of platelet-rich plasma therapy in dermatology, highlighting recent research findings and discussing its potential and limitations without reporting new clinical results.
research Berberine as a Modulator of Metabolic and Hormonal Dysregulation in PCOS: Mechanisms of Action and Clinical Implications - A Narrative Review
This study suggests that berberine may offer multiple benefits for women with polycystic ovary syndrome by improving metabolic and hormonal profiles, though further research is needed on its long-term effects on reproductive outcomes.
research Use of network pharmacology and molecular docking to explore the mechanism of action of betulinic acid in the treatment of alopecia
This study used computational methods to explore the potential of betulinic acid from Ziziphus spina-christi in treating alopecia, suggesting its possible protective effects on hair follicles by enhancing genomic stability and reducing oxidative damage, meriting further experimental validation.
research Reduction in Hair Waviness by Rubbing Hair Treatments into Hair and Its Mechanism of Action
This study found that massaging hair treatments into hair improved the treatment's effectiveness by reducing hair waviness and enhancing shape cohesion.