Predictive Modeling of Drug Response and Mechanism of Action in Alopecia Areata Clinical Trials

    April 2017 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    J.C. Chen, Ali Jabbari, Raphael Clynes, J. Mackay-Wiggin, Angela M. Christiano
    TLDR Researchers found three different ways drugs work to treat hair loss from alopecia areata and identified key factors for personalized treatment.
    The study focused on alopecia areata (AA), an autoimmune disease causing hair loss, and explored the molecular mechanisms behind drug responses in clinical trials. Researchers identified JAK/STAT and T cell costimulatory pathways as key targets and analyzed the molecular responses to three drugs: tofacitinib, ruxolitinib, and abatacept. By using RNAseq data from scalp biopsies and reverse-engineered regulatory networks, they modeled the mechanisms of action for these drugs. The study found distinct molecular mechanisms for each drug, which could be captured by a small number of transcription factors. This systems biology approach aimed to enhance precision medicine strategies, allowing for better treatment selection based on individual molecular pathology.
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      community What else is good. Besides the big 3.

      in Chat  36 upvotes 1 month ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 1 year ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

      community any news about DUPA (Diffuse unpatterned alopecia)?

      in Research/Science  11 upvotes 1 year ago
      The conversation discusses diffuse unpatterned alopecia (DUPA) and its possible causes, including sensitivity to DHT, not being androgenic alopecia, being diffuse alopecia areata, or hormonal issues. Treatments mentioned include topical melatonin, Clobetasol Propionate for alopecia areata, and the lack of results from using finasteride, dutasteride, and minoxidil.

      community 22F. Should I even bother getting a biopsy? Is there any point?

       8 upvotes 8 years ago
      A woman who has been experiencing hair loss for several years, and her question of whether there is any benefit to getting a biopsy to check if it's AGA or diffuse alopecia areata when no cure or very effective treatment exists. Treatments such as spironolactone and Minoxidil/finasteride/RU58841 have previously been discussed.

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