Alteration of Serum and Tissue Tumor Necrosis Factor Alpha Levels: A Possible Mechanism of Action of Oral Pulse Steroids in the Treatment of Alopecia Areata

    October 2018 in “ Journal of Cosmetic Dermatology ”
    Dalia Abdel Halim, Ola M. Abu Zeid, Laila Rashed, Marwah Adly Saleh
    TLDR Oral pulse steroids reduce TNF-α levels, improving alopecia areata.
    The study investigated the effect of oral pulse steroids on TNF-α levels in 20 patients with alopecia areata (AA). Results showed that both serum and tissue TNF-α levels were significantly higher in AA patients compared to controls before and after treatment. However, TNF-α levels significantly dropped after treatment, correlating positively with clinical improvement. The findings suggested that TNF-α played a crucial role in AA and that altering its levels could be a key mechanism by which oral pulse steroids treat AA.
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      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      by MagicBold in Research  865 upvotes 1 year ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community This guy loses all transplanted hair?!

      in Transplants  160 upvotes 1 year ago
      A man lost his transplanted hair despite using minoxidil because he wasn't on a DHT blocker like finasteride, which is essential to prevent further hair loss. The conversation emphasizes that hair transplants are not a cure and require maintenance with medications to preserve results.

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      in Progress Pictures  7 upvotes 2 years ago
      A user is experiencing worsening hair loss despite using 8mg of oral finasteride and is considering trying minoxidil or redoing blood work. They are concerned about thinning hair on the sides and back of their head.

      community Month 6 on oral fin/min no stabilisation at all still shedding big

      in Chat  24 upvotes 1 year ago
      The user has been on oral finasteride and minoxidil for six months without seeing hair loss stabilization and has started taking dutasteride twice a week. Other users shared their experiences with hair loss treatments, with one suggesting dutasteride might be more effective than finasteride.

      community Diffuse thinning is so brutal.

      in Styling  73 upvotes 2 years ago
      A 25-year-old with AGA experienced hair thinning and dandruff, stabilized with topical finasteride and minoxidil but saw minimal regrowth. They seek advice on styling and consider oral minoxidil and microneedling for denser hair.

      community Well here I am 3-4 years later.

      in Update  56 upvotes 2 years ago
      The conversation is about someone who has been taking finasteride for hair loss without success, considering switching to dutasteride or giving up treatment. Suggestions include trying dutasteride, microneedling, infrared therapy, multivitamins, and high-concentration topical solutions combining finasteride and dutasteride.

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