Screening of New Agents for Hair Growth and Their Mechanisms of Action

June 1996 in “ Journal of Dermatological Science ”

A Shiraj, Toshikazu Kamiya, Sagano Kawashima, Tatsuya Tamaoki, Junichi Ikeda, Satoshi Mouri, Tomokatsu Kawakita

hair growth alopecia tissue culture system C3H mice hair regrowth KF19418 KF15773 minoxidil hair matrix cells hair follicles Rogaine

TLDR Two new compounds were found that could promote hair growth as well or better than minoxidil.

In 1996, researchers screened various synthesized compounds to identify new agents that could promote hair growth and combat alopecia. They developed an original tissue culture system using 4-week-old C3H mice for initial screening. Following this, they tested the hair regrowth activity of selected compounds on hair-clipped mice. Two compounds, KF19418 and KF15773, were identified as having hair growth promoting activity equal to or higher than minoxidil. KF19418, at a concentration of 10 μM, increased cell proliferation in the hair matrix cell culture system by four to six times compared to the control, indicating a direct effect on hair matrix cells. KF15773, however, did not show a promotive effect on cell growth in the same system, suggesting it may target different cells within the hair follicles.

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