Screening of New Agents for Hair Growth and Their Mechanisms of Action

June 1996 in “ Journal of Dermatological Science ”

A Shiraj, Toshikazu Kamiya, Sagano Kawashima, Tatsuya Tamaoki, Junichi Ikeda, Satoshi Mouri, Tomokatsu Kawakita

hair growth alopecia tissue culture system C3H mice hair regrowth KF19418 KF15773 minoxidil hair matrix cells hair follicles Rogaine

TLDR Two new compounds were found that could promote hair growth as well or better than minoxidil.

In 1996, researchers screened various synthesized compounds to identify new agents that could promote hair growth and combat alopecia. They developed an original tissue culture system using 4-week-old C3H mice for initial screening. Following this, they tested the hair regrowth activity of selected compounds on hair-clipped mice. Two compounds, KF19418 and KF15773, were identified as having hair growth promoting activity equal to or higher than minoxidil. KF19418, at a concentration of 10 μM, increased cell proliferation in the hair matrix cell culture system by four to six times compared to the control, indicating a direct effect on hair matrix cells. KF15773, however, did not show a promotive effect on cell growth in the same system, suggesting it may target different cells within the hair follicles.

View this study on jdsjournal.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Solving Hair Loss with Research at MIT

in Research/Science 590 upvotes 1 month ago

Hair loss treatments like minoxidil, finasteride, TDM-105795, and PP405. MIT is hosting a hackathon to find innovative hair loss solutions.

community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 5 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

community I find it crazy how some people like this bloke have 0 DHT sensitivity. He is on grams of anabolic steroids and has a full, thick head of hair. I wish all of on here had this guys hair genes lol

in Satire 443 upvotes 1 year ago

The conversation is about hair loss and the possibility of maintaining a full head of hair while using anabolic steroids. Some users believe that having good hair genes and taking hair loss protocols can help prevent hair loss while on steroids.

community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

in Research/Science 732 upvotes 2 years ago

A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 1 month ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community 6 month progress. Fin/Min daily.

in Progress Pictures 506 upvotes 3 years ago

A user's 6 month progress using finasteride and minoxidil as treatments for hair loss, with the replies discussing side effects and general consensus about usage of the two medications.

Related Research

3 / 3 results

research Promotion of Hair Growth in Alopecia Areata by Topical Treatment of HDAC Inhibitors

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

HDAC inhibitors, like Vorinostat and Entinostat, can help regrow hair in alopecia areata.

research Interventions for Alopecia Areata

2 citations, February 2009 in “Journal of Evidence-Based Medicine”

No treatment showed significant long-term hair growth benefits for alopecia areata.

research Topical Minoxidil in the Treatment of Alopecia Areata

80 citations, October 1983 in “BMJ”

Minoxidil helps hair regrowth in alopecia patients, with 16 having good results and no side effects.