TLDR Vitamin D and its receptor are crucial for bone health and can be influenced by certain fats and curcumin.
The study explored the role of the vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], in regulating calcium and phosphate metabolism through its interaction with the nuclear vitamin D receptor (VDR) and its retinoid X receptor (RXR) partner. It highlighted the reciprocal relationship between 1,25(OH)(2)D(3) and fibroblast growth factor 23 (FGF23) in controlling phosphate levels, similar to the 1,25(OH)(2)D(3)-PTH axis for calcium regulation. The research also identified novel VDR ligands, including omega3/omega6 polyunsaturated fatty acids (PUFAs) and curcumin, which could activate VDR independently of 1,25(OH)(2)D(3), suggesting potential new pathways for VDR-mediated effects in various tissues, including bone, intestine, and skin/hair follicles.
104 citations,
May 2003 in “Endocrinology” Lampreys have a functional vitamin D receptor that may help detoxify harmful substances.
1308 citations,
March 1998 in “Journal of bone and mineral research” The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.
271 citations,
September 2008 in “Nutrition reviews” Vitamin D receptor interacts with certain dietary components to help prevent diseases and regulate hair growth.
1308 citations,
March 1998 in “Journal of bone and mineral research” The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.
17 citations,
April 2007 in “Kidney international” Vitamin D boosts a specific gene activity in kidney cells that could improve heart and kidney function.
158 citations,
August 2011 in “Reviews in endocrine and metabolic disorders” Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.
1533 citations,
October 2008 in “Endocrine reviews” Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.
December 2017 in “Elsevier eBooks” The vitamin D receptor helps maintain hair and bone health even without binding vitamin D.
