Vitamin D Receptor: Key Roles in Bone Mineral Pathophysiology, Molecular Mechanism of Action, and Novel Nutritional Ligands

    December 2007 in “ Journal of bone and mineral research ”
    Peter W. Jurutka, Leonid Bartik, G. Kerr Whitfield, Douglas R. Mathern, Thomas K. Barthel, M. I. Gurevich, Jui Cheng Hsieh, Magdalena Kaczmarska, Carol A. Haussler, Mark R. Haussler
    TLDR Vitamin D and its receptor are crucial for bone health and can be influenced by certain fats and curcumin.
    The study explored the role of the vitamin D hormone, 1,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], in regulating calcium and phosphate metabolism through its interaction with the nuclear vitamin D receptor (VDR) and its retinoid X receptor (RXR) partner. It highlighted the reciprocal relationship between 1,25(OH)(2)D(3) and fibroblast growth factor 23 (FGF23) in controlling phosphate levels, similar to the 1,25(OH)(2)D(3)-PTH axis for calcium regulation. The research also identified novel VDR ligands, including omega3/omega6 polyunsaturated fatty acids (PUFAs) and curcumin, which could activate VDR independently of 1,25(OH)(2)D(3), suggesting potential new pathways for VDR-mediated effects in various tissues, including bone, intestine, and skin/hair follicles.
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