Vitamin D Receptor: Key Roles in Bone Mineral Pathophysiology, Molecular Mechanism of Action, and Novel Nutritional Ligands

December 2007 in “ Journal of bone and mineral research ”

Peter W. Jurutka, Leonid Bartik, G. Kerr Whitfield, Douglas R. Mathern, Thomas K. Barthel, M. I. Gurevich, Jui Cheng Hsieh, Magdalena Kaczmarska, Carol A. Haussler, Mark R. Haussler

vitamin D receptor 1,25-dihydroxyvitamin D(3) VDR retinoid X receptor RXR fibroblast growth factor 23 FGF23 parathyroid hormone PTH omega3 polyunsaturated fatty acids omega6 polyunsaturated fatty acids PUFAs curcumin hair follicles omega3 PUFAs omega6 PUFAs

Studysummary This study suggests that 1,25-dihydroxyvitamin D(3) and fibroblast growth factor 23 form a crucial axis in regulating phosphate balance, akin to its role in calcium regulation, and explores novel VDR interactions including with curcumin.

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