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This study reviewed the challenges of delivering nucleic acids for gene therapy, highlighting the limitations of non-viral vehicles and exploring bioinspired strategies using cell membrane camouflage for improved delivery efficacy.

In this study, the novel fatty acid-conjugated tetrapeptide Palmitoyl-GDPH enhanced wound healing in rats by improving re-epithelialization and collagen deposition with minimal toxicity observed at the used dosage.

This study found that a 5 µM concentration of simvastatin significantly increased the differentiation of hair follicle stem cells into keratinocytes in vitro.

This review discusses how extracellular vesicles play a dual role in age-related diseases by contributing to both disease pathogenesis and potential therapeutic strategies through the transfer of specific molecules.

This study highlights that while hair follicle cycling is primarily influenced by growth factors like IGF-1 and Wnt signals, the role of cytokines in normal human hair growth and cycling is less understood.

This paper critically reviews recent advances in the use of keratin-based biomaterials, highlighting their potential applications in wound healing, drug delivery, and tissue regeneration due to their biocompatibility, biodegradability, and ability to support cell growth.

This review discusses the role of tissue mechanics and extracellular matrix in skin aging processes and highlights potential therapeutic strategies, but reports no new clinical results.

This study describes a method to extract and characterize keratin particles from human hair, finding they can encapsulate the anticancer drug Paclitaxel with significant efficiency, releasing it in a pH-dependent manner potentially beneficial for targeted cancer treatment.

This study found that incorporating hair follicle-primed spheroids into skin constructs showed potential for developing hair-bearing skin mimetics with follicle-forming abilities in vitro.

Using a transgenic pig model, this study demonstrated that LGR5 is a marker of hair follicle stem cells across different species, with important similarities and differences in gene expression and developmental processes.

This study found that incorporating PCL-based nanoscaffolds into liver spheroids enhances their viability and liver-specific biofunctionality, suggesting these scaffolds improve the model's potential for preclinical drug screening by increasing sensitivity to acetaminophen toxicity compared to traditional methods.

This article reviews recent developments in microneedles combining metallic elements and herbal compounds for wound healing, highlighting their benefits such as enhanced therapeutic efficacy and reduced toxicity, and offering a reference for future advancements in this technology.

In this study, researchers developed an in vitro airway-organoid model using human lung-derived cell lines on RADA16-I hydrogels to serve as a potential tool for studying adenovirus isolation, pathogenesis, and antiviral drug screening.

This study found that mesenchymal stem cells sourced from hair follicle outer root sheath showed higher differentiation efficiency and angiogenic potential for vascular graft applications compared to adipose-derived stem cells.

This study demonstrated that Wnt5a can serve as an orienting signal for mouse skin's planar cell polarity but its overexpression disrupts hair follicle orientation, which can be rescued by modifying Fzd6 levels.

This study found that UC.145 influences DKK1 methylation and Wnt signaling in gastric cancer, with implications for patient survival and its potential as a predictive biomarker.

This study mapped gene expression in different skin structures of dogs, finding similarities to humans that support using dogs as models for human skin diseases.

This study found that GDNF promotes hair formation and skin wound repair by enhancing the self-renewal and differentiation of bulge stem cells in mice.

This review discusses the potential of adipose-derived stem cell extracellular vesicles (ADSC-EVs) in skin regeneration, highlighting mechanisms like inflammation and angiogenesis, but reports no new clinical results; challenges and future prospects are also considered.

This study introduces a novel in vitro model for clubfoot fibrosis to enable high-throughput drug screening and found that while the model increased collagen deposition, the antifibrotic drug minoxidil effectively inhibited the expression of collagen cross-linking enzymes.

This study found that the expression of the sonic hedgehog protein is involved in wound healing texture regeneration, inhibiting skin texture after embryonic day 14 and affecting keratinocyte migration and division.

This study found that while zebularine did not significantly accelerate wound healing, it improved the quality of restored skin in mice, suggesting potential for further research into epigenetic inhibitors.

This study observed that in patients with diabetic foot ulcers, an imbalance in skin microbiota, with increased pathogenic bacteria, contributes to infection and poor wound healing, and suggests that modulating microbiota composition might improve healing outcomes.

This study reviewed the use of 3D printing and bioprinting for tympanic membrane repair, comparing them with traditional materials and noting their clinical significance, while highlighting the need for further analysis of bio-ink selection strategies involving biopolymers, cells, and drugs.

This study developed a smart PVA-TPE/HA-AMP/SF/ALG wound dressing that shows promise in infected wound healing by providing bacterial resistance, promoting cell proliferation, and modulating inflammation through various signaling pathways, potentially reducing scar formation.

In this animal study, oral administration of wedelolactone significantly improved bone mineral density and reduced osteoclast numbers in a model of particle-induced osteolysis, suggesting potential as a treatment option.

This study found that a hydrogel containing icariin enhanced wound healing and hair-follicle regeneration in vivo by promoting M2 macrophage polarization and modulating the BMP pathway, with treated skin defects showing improved recovery and new hair follicle development compared to untreated defects.

This review discusses the effects of calorie restriction on skin aging, highlighting its potential to benefit skin health by reducing age-related and photo-induced changes, although the impact of certain diets remains unexplored.

In this study, researchers identified Tenascin-C as a marker for touch dome keratinocytes, which maintain themselves and can develop into Merkel cells following injury, showing they share molecular traits with various epidermal keratinocytes.

This study found that using a shampoo containing heat-killed probiotics, GMNL-653, led to decreased dandruff and sebum production and increased hair growth in human participants, with observed microbiota shifts including changes in M. globosa and M. restricta abundance.