Antimicrobial Peptide-Modified AIE Visual Composite Wound Dressing for Promoting Rapid Healing of Infected Wounds

The study explores a novel antimicrobial peptide-modified AIE visual composite wound dressing, PVA-TPE/HA-AMP/SF/ALG, designed to promote rapid healing of infected wounds. This dressing effectively reduces bacterial infection, enhances cell proliferation, and promotes angiogenesis. In vitro tests showed a 99.99% antibacterial rate against S. aureus and 84.63% against E. coli. In vivo experiments on mice demonstrated significant acceleration in wound closure, with complete healing within 10 days. The dressing's ability to deliver AMP and TPE continuously contributes to its antimicrobial efficacy and enhanced tissue regeneration, reducing inflammation and promoting collagen deposition without excessive scarring. It also increases VEGF expression, supporting angiogenesis and wound healing. The dressing shows no toxicity in biosafety evaluations, indicating its potential for safe use in wound treatment. Further evaluation is needed to assess its long-term biosafety and effectiveness in larger mammals.