Antibacterial Quaternary Ammonium Chitosan/Carboxymethyl Starch/Alginate Sponges with Enhanced Hemostatic Property for the Prevention of Dry Socket

    January 2023 in “ Frontiers in Bioengineering and Biotechnology ”
    Xuyang Deng, Danyang Wang, Dongjie Zhang, Ming Sun, Liying Zhou, Yuxi Wang, Xiaowen Kong, Changqing Yuan, Qihui Zhou
    Studysummary This study reported that newly developed quaternary ammonium chitosan/carboxymethyl starch/alginate sponges effectively inhibit bacterial growth and promote rapid hemostasis in wound management after tooth extraction in animal models, showing significant promise for clinical use in preventing complications like dry socket.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The study developed antibacterial quaternary ammonium chitosan/carboxymethyl starch/alginate (ACQ) sponges with enhanced hemostatic properties to prevent dry socket after tooth extraction. These sponges, created through Ca2+ crosslinking and lyophilization, demonstrated superior antibacterial and hemostatic capabilities compared to traditional methods. In vitro and in vivo tests, including models with mice and pigs, confirmed their effectiveness in promoting hemostasis and reducing blood loss. The sponges showed high cell viability, effective inhibition of bacteria like E. coli, S. aureus, and C. albicans, and rapid blood clotting with low hemolysis rates, indicating their potential as a multifunctional dressing for dental applications.
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