Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study found that SHJH hr mice, with a Hairless gene mutation, exhibit accelerated skin aging potentially due to poor antioxidative protection, highlighting the Hr gene's role in skin aging.

In this study, oral administration of Lactococcus lactis strain H61 to senescence-accelerated mice was linked to reduced bone density loss, less skin ulcer incidence, and reduced hair loss, along with altered immune responses.

In this study, researchers found that frontal hair follicles in individuals with androgenetic alopecia show a higher biological age compared to occipital follicles, possibly due to decreased expression of the transcriptional repressor TRPS1 in frontal dermal papillae, which may influence follicle miniaturization.

This study found that sustained intracellular acidosis in mice was associated with shortened lifespan, early aging signs, and impaired autophagy.

This review discusses the commonly observed pathological findings in progeroid mouse models and highlights the importance of understanding mouse strain backgrounds and progeria-related phenotypes for accurate pathology data interpretation.

In a dermal Gorab knockout mouse model, this study found that Gorab mutations increase P53 protein accumulation and disrupt extracellular matrix expression, contributing to accelerated skin aging and suggesting a pathway involving epigenetic regulation.

This study found that transient mtDNA double strand breaks in mice accelerated aging in certain tissues through increased reactive oxygen species, independent of p21/p53 pathway mediation.

In this study, lifelong barley intake in SAMP8 mice was associated with extended lifespan, improved aging-related phenotypes, and beneficial shifts in the intestinal microbiome.

This study found that high-dose radiation can induce accelerated cellular senescence, inflammation, and loss of epithelial stem cells in mouse and human skin, contributing to radiation dermatitis.

This study comparatively evaluated different extraction techniques for Schinus terebinthifolius Raddi leaf extracts and found that conventional extraction with ethanol yielded the highest antioxidant activity and beneficial effects on skin cell viability, supporting its potential use in sustainable cosmeceutical formulations targeting skin aging.

This study found that androgen/androgen receptor signaling accelerates premature senescence in dermal papilla cells, highlighting a potential target for treating androgenetic alopecia.

This case report from Nepal describes a five-year-old boy with Hutchinson Gilford Progeria Syndrome experiencing ocular manifestations, highlighting the role of ocular senescence in this genetic disorder.

This study reported that urban pollution accelerates facial wrinkle development and increases pigmentation severity in Chinese women over 30, whereas UV exposure affects these signs from age 20. After 45, pollution becomes a key contributor to skin aging.

This narrative review highlights the need for diabetes-informed approaches to aesthetic dermatology as accelerated skin aging in diabetic patients complicates the safety and effectiveness of cosmetic procedures.

This study suggests that selenium deficiency accelerates aging-related health deterioration in mice with short telomeres, providing a model for exploring selenium’s role in human aging.

This review examines how male facial anatomy and behavior contribute to sexual dimorphism in facial aging, pointing to factors that accelerate aging in men but presents no new clinical results.

This review details the development and genetic background of senescence-accelerated mouse strains, provides a comprehensive examination of their phenotypes, and highlights their importance for aging research, but reports no new experimental results.

This study reviews how individuals with diabetes experience accelerated skin aging and explores the implications for cosmetic treatments, highlighting the need for diabetes-informed dermatologic approaches due to limited evidence on safety and efficacy in this population.

In this study on C57BL/6 mice, researchers found that cadmium chloride exposure led to metabolic disruption, accelerated skin aging, and impaired hair regeneration, with more severe effects observed at higher doses.

This review discusses Hutchinson-Gilford progeria syndrome, highlighting its phenotype, pathogenesis, and its potential insights into natural aging and cardiovascular diseases, but it reports no new research findings.

This study found that transgenic mice expressing a mutant CYLD protein lacking deubiquitinase function showed signs of premature aging and spontaneous tumor development, likely due to over-activation of specific molecular pathways and chronic inflammation.

This study found that stabilizing β-catenin in a specific mouse model led to temporarily increased hair density but ultimately accelerated hair follicle aging and hair thinning.

This review summarizes recent research into the effects of GLP-1 receptor agonists on skin processes, noting potential benefits for wound healing but also potential cosmetic concerns like facial fat loss and decreased collagen, highlighting the need for more clinical studies to clarify their dermatological impact.

This review discusses the molecular mechanisms driving hair follicle degeneration in skin aging and emphasizes the role of the tissue microenvironment on stem cell function, but reports no new research findings.

This study found that a topical cream containing CBD and EPA reduced signs of extrinsic skin aging, including wrinkle volume and skin elasticity, in clinical and laboratory settings.

This narrative review explores how psychological stress may contribute to premature skin aging by affecting dermal collagen and elastin remodeling through neuroendocrine, molecular, and cellular pathways, highlighting potential therapeutic targets to preserve skin structure and function.

This narrative review emphasizes the relationship between metabolic syndrome, metabolic aging, and skin manifestations, highlighting cases like early-onset androgenetic alopecia linked with insulin resistance, and underscores their significance for dermatology and aesthetic practice.

BrdU speeds up hair follicle aging and reduces hair quality.

This study suggests that both age and photoexposure may decrease maximum viable epidermis thickness and impact the dermal-epidermal junction in women with Fitzpatrick skin types II-III.

This study suggests that short telomeres may produce similar aging-related symptoms across different segmental progeroid syndromes, offering potential insights into normative aging processes.