Association of DNA Damage with Vitamin D and Hair Heavy Metals in Obese Women

    June 2021
    Chiat Yin Ng, Farahnaz Amini, Normina Ahmad Bustami, Eugenie Sin Sing Tan, Pui Yee Tan, Soma Mitra
    Image of study
    TLDR Adequate vitamin D might lower, and high hair chromium might increase DNA damage in obese women.
    The study with 134 women aged 20 to 50 years found that 96.3% had vitamin D deficiency and there was no significant difference in serum 25(OH)D levels, DNA damage indicators, hair heavy metal concentrations, and dietary nutrients between obese and non-obese groups. However, in obese women, higher serum 25(OH)D levels (≥31 nmol/L) were associated with less DNA damage, while higher hair chromium concentrations (≥5.88 mg/kg) were associated with more DNA damage. The study suggests that adequate vitamin D levels might reduce, and high chromium levels might increase DNA damage in obese individuals, although causal relationships could not be established.
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