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This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Finasteride helps protect brain in old male rats.

Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Activating TSPO helps protect the retina from damage caused by high eye pressure in glaucoma.

Finasteride raises suicide-linked aggression and stops clozapine's positive effects in schizophrenia animals.

Finasteride worsens stress effects on sensory processes, possibly linking to anxiety/depression.

Diet changes hormone levels in pregnant ewes by affecting metabolism, not placental synthesis.

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

Finasteride and dutasteride reduce unwanted movements from Parkinson's disease treatment by normalizing certain brain signals.

Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

Finasteride treatment can decrease certain steroids and increase others, possibly leading to depression symptoms in some cases.

Gut microbes significantly affect brain steroid levels.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

Post-finasteride syndrome causes lasting sexual, neurological, and physical side effects in some people after taking finasteride.

Finasteride may cause long-lasting sexual side effects.

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Stress worsens Tourette symptoms by increasing allopregnanolone levels.

Finasteride may increase depression by reducing brain cell growth.