Inhibition of 5α-Reductase Alters Pregnane Metabolism in the Late Pregnant Mare
March 2018
in “
Reproduction
”
TLDR Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.
In this study, pregnant mares (n = 5) treated with the 5α-reductase inhibitor dutasteride showed a sixfold increase in progesterone concentrations compared to control mares (n = 4), while other 5α-reduced pregnanes remained unchanged. Dutasteride treatment did not significantly affect gestational length or neonatal outcomes. The findings suggested that inhibiting 5α-reductase led to an accumulation of progesterone, indicating that dutasteride can alter progesterone metabolism during late gestation in mares.
