Inhibition of 5α-Reductase Alters Pregnane Metabolism in the Late Pregnant Mare

    January 2018 in “ Reproduction ”
    Michelle A.A. Wynn, Barry A. Ball, Erin Legacki, Alan J Conley, Shavahn C. Loux, John May, Alejandro Esteller-Vico, Scott D Stanley, Kirsten E. Scoggin, E.L. Squires, Mats H.T. Troedsson
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    TLDR Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.
    In this study, pregnant mares (n = 5) treated with the 5α-reductase inhibitor dutasteride showed a sixfold increase in progesterone concentrations compared to control mares (n = 4), while other 5α-reduced pregnanes remained unchanged. Dutasteride treatment did not significantly affect gestational length or neonatal outcomes. The findings suggested that inhibiting 5α-reductase led to an accumulation of progesterone, indicating that dutasteride can alter progesterone metabolism during late gestation in mares.
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