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The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Finasteride might affect memory by impacting cholinergic system.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

Low dose finasteride decreases certain steroids, possibly increasing depression risk.

Changing neuroactive steroids in baby male rats affects their memory and learning differently as they grow up.

Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.

Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.

Neuroactive steroids may affect the risk and treatment of alcohol use disorders.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

Finasteride may increase depression by reducing brain cell growth.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

Fluoxetine's effectiveness as an antidepressant in mice depends on a specific protein activity and a 5-minute pretest.

Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.

Progesterone initially worsens but later reduces neuropathic pain in mice, through different mechanisms.

Allopregnanolone increases growth and changes gene activity in human brain cancer cells.

Finasteride and dutasteride reduce neurosteroid production, possibly helping treat glioblastoma.

Finasteride raises suicide-linked aggression and stops clozapine's positive effects in schizophrenia animals.

Cocaine impairs male sexual behavior and alters testosterone metabolism in the brain.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Finasteride reduces alcohol withdrawal severity in male mice but increases it in female mice.

Post-finasteride syndrome causes lasting sexual, neurological, and physical side effects in some people after taking finasteride.

Finasteride reduces response to stress and rewards, affecting behavior and mental health.

Neurosteroids can influence behavior by modulating brain inhibition, with potential for treating psychiatric disorders.