July 2020 in “Vestnik urologii” The cause of post-finasteride syndrome is unclear and needs more research.
153 citations,
April 2009 in “Urology” Prostate cancer was a major health issue in 2009, especially for Black men, and targeting the 5alpha-reductase enzyme could help in its prevention and treatment.
23 citations,
March 2001 in “Clinics in Dermatology” Hair restoration surgery techniques have evolved, with focus on patient selection and realistic goals, and future advancements may include cloning and gene therapy.
August 2024 in “Cosmetics” Personalized treatments for hair loss are becoming more effective by using genetic information.
December 2018 in “Actas urológicas españolas” 5-alpha reductase inhibitors may have additional effects on cancer, mental health, heart health, and hormone levels beyond treating prostate enlargement.
70 citations,
June 1993 in “Biochemistry” Finasteride slowly binds to 5-alpha-reductase, affecting enzyme stability and inhibitor potency.
5 citations,
May 2020 in “Dermatologic Therapy” 5-alpha reductase inhibitors might worsen lung recovery in COVID-19 patients, suggesting a pause in their use.
March 2016 in “European Urology Supplements” Methylation in specific gene region causes finasteride resistance in some BPH patients.
71 citations,
November 2012 in “Expert Opinion on Drug Safety” 5-alpha reductase inhibitors can cause sexual side effects like erectile dysfunction and reduced sexual desire, sometimes lasting after stopping the drug.
18 citations,
January 2011 in “Bioorganic & Medicinal Chemistry Letters” New hybrid compound found to effectively prevent hair loss.
8 citations,
June 2017 in “Steroids” New chemical compounds were made that effectively block an enzyme linked to prostate growth.
3 citations,
January 2022 in “Precision medicine and clinical omics” Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.
1 citations,
January 2019 in “Journal of the Egyptian Women's Dermatologic Society (Print)” Minoxidil 2% is more effective for female hair loss, but botanicals have fewer side effects.
122 citations,
November 2010 in “Journal of Dermatological Science” Male pattern baldness involves hormones and cell signals affecting hair growth.
23 citations,
May 2019 in “Expert Opinion on Therapeutic Patents” New androgen receptor modulators show promise for treating diseases like prostate cancer and muscle wasting.
22 citations,
August 2009 in “Evidence-based Complementary and Alternative Medicine” The composition with carnitine, thioctic acid, and saw palmetto extract may effectively reduce inflammation in hair follicle cells.
131 citations,
August 2000 in “International Journal of Dermatology” Inflammation may be linked to hair loss, and targeting specific enzymes could help treat it.
52 citations,
September 2018 in “International Journal of Molecular Sciences” Ginseng and its compounds may help hair growth and prevent hair loss, but more human trials are needed to confirm this.
18 citations,
February 2018 in “International Journal of Molecular Sciences” PGD2 increases androgen receptor activity in hair cells, which could be targeted to treat hair loss.
12 citations,
October 2013 in “The Prostate” Dutasteride and finasteride affect different cell types differently.
17 citations,
April 2015 in “Tropical Journal of Pharmaceutical Research” Asiasari Radix et Rhizoma is safe and has potential for new drug development due to its therapeutic properties.
69 citations,
February 2002 in “International Journal of Cosmetic Science” Some hair loss can be treated, especially in women due to nutrition, but some types remain untreatable.
12 citations,
October 2004 in “Experimental Gerontology” Changes in testosterone and estrogen receptor genes can affect how men age, influencing body fat, hair patterns, and possibly leading to skin disorders.
January 2019 in “Actas urológicas españolas” Using mirabegron and solifenacin together is safe and more effective for treating overactive bladder than using either drug alone.
September 2015 in “Korean Journal of Clinical Pharmacy” Dutasteride is highly effective for hair loss treatment in Korea, with more side effects than finasteride.
2 citations,
April 2021 in “Canadian Journal of Urology” Five-alpha reductase inhibitors, like finasteride and dutasteride, can treat enlarged prostates, improve urination, reduce need for prostate surgery, and lower the risk of prostate cancer, but may increase the risk of higher grade prostate cancer. They can also treat male pattern baldness.
April 2023 in “European urology open science” Urologists should screen for mental health issues before and during finasteride treatment.
August 2024 in “Cosmetics” Peanut callus extract helps grow hair and prevent hair loss.
8 citations,
June 2022 in “Cosmetics” Coffee berry extract may help slow skin aging and prevent hair loss.
January 2022 in “Food Science and Technology” The herbal mixture could potentially improve hair loss.