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The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Finasteride negatively affects fish reproduction and gonadal development.

Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.

Finasteride affects urinary steroid profiles and can potentially hide steroid abuse in sports drug testing.

Finasteride effectively treats male hair loss, improving growth and density.

Finasteride and dutasteride reduce unwanted movements from Parkinson's disease treatment by normalizing certain brain signals.

Dutasteride reduces DHT more effectively than finasteride.

Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.

Finasteride doesn't affect sleep spindles in men.

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

Two types of 5α-reductase are in dog skin, which might make dutasteride better than finasteride for treating dog hair loss.

Finasteride effectively reduces hair growth in women with idiopathic hirsutism, but requires careful contraception during treatment.

Long-term finasteride use doesn't change bone density or metabolism.

Dutasteride may help shrink prostate cancer tumors.

Low dose finasteride decreases certain steroids, possibly increasing depression risk.

High doses of finasteride cause cell growth and tumors in mice.

Finasteride causes abnormal growth in male mice cells at high doses.

Pueraria mirifica extract may help treat benign prostatic hyperplasia.

Glioblastoma cells can make androgens, which might help the tumor grow.

Reduced androgens linked to kinky hair disorder and hair loss; 5a-reductase inhibitors may help.

Finasteride and dutasteride may cause metabolic issues like liver disease and diabetes.

Three natural compounds from Ghanaian plants may help treat BPH and alopecia.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

BB4CMU rice bran oil may help treat hair loss and gray hair.

Dutasteride more effectively lowers DHT levels in men with enlarged prostates than finasteride.

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

PNU 157706 is a more effective treatment than finasteride for conditions caused by DHT, like enlarged prostate and hair loss.

Neuroactive steroids and the enzyme 5α-reductase might be involved in the development of Tourette's syndrome.

Ficus benghalensis leaf extracts can effectively promote hair growth and inhibit hair loss.

Men with early balding showed higher levels of certain genes linked to hair loss and possibly prostate cancer.