4 citations
,
April 2018 in “British Journal of Dermatology” Finasteride for female hair loss has low side effects, more research needed.
9 citations
,
January 2018 in “American Journal of Men's Health” This study analyzed self-reports from discussion forums to categorize and understand adverse effects experienced by individuals using finasteride, suggesting a need for further investigation into post-finasteride syndrome.
58 citations
,
April 2017 in “The Journal of Steroid Biochemistry and Molecular Biology” This study found that patients with post-finasteride syndrome exhibited major depressive disorder, severe erectile dysfunction, and neuropathy, alongside altered neuroactive steroid levels in cerebrospinal fluid.
50 citations
,
March 2017 in “PeerJ” This study found that longer exposure to 5α-reductase inhibitors significantly increased the risk of persistent erectile dysfunction, especially in younger men exposed to finasteride.
8 citations
,
February 2017 in “Clinical Drug Investigation” This paper discusses the adverse effects of finasteride, including sexual dysfunction and depression, and suggests that treatment customization based on individual factors like hand preference and sexual orientation could improve outcomes and reduce these side effects.
10 citations
,
January 2017 in “Skin Pharmacology and Physiology” This case report describes a 52-year-old man who developed generalized vitiligo two months after stopping finasteride and suggests this may be part of post-finasteride syndrome.
14 citations
,
December 2016 in “Sexual Medicine” This study identified differences in adverse symptoms among patients with post-finasteride syndrome based on short and long androgen receptor gene polymorphisms.
1 citations
,
November 2016 in “Journal of the Dermatology Nurses’ Association” This article reviews the mechanism, use, and alternatives for finasteride in dermatology and provides no new clinical results.
50 citations
,
September 2016 in “The Journal of Clinical Endocrinology and Metabolism” This study found no evidence of androgen deficiency or decreased peripheral androgen action in men with persistent sexual symptoms after finasteride use, but identified links to depressed mood and abnormal brain function.
57 citations
,
July 2016 in “The Journal of Sexual Medicine” This study concluded that 5α-reductase inhibitors were linked to increased sexual dysfunction in men with benign prostatic hyperplasia, but not in men with androgenetic alopecia.
8 citations
,
May 2016 in “Indian Journal of Pharmacology” This case report describes an atypical postfinasteride syndrome in a patient treated with both dutasteride and finasteride for androgenic alopecia, highlighting its multisystem involvement and irreversible nature.
31 citations
,
February 2016 in “American Journal of Men's Health” This study found that nearly half of men using finasteride reported clinically significant depression, highlighting the need for psychiatric screening and careful risk assessment by prescribing clinicians.
43 citations
,
January 2016 in “International Journal of Andrology” This study found that men experiencing long-term symptoms after finasteride use for androgenetic alopecia frequently reported loss of penis sensitivity and anhedonia, among other effects, indicating potential post-finasteride syndrome.
20 citations
,
June 2015 in “Hormone Molecular Biology and Clinical Investigation” This study found that long-term finasteride therapy in men with BPH worsened erectile dysfunction and reduced testosterone levels, while these effects were not observed with tamsulosin.
36 citations
,
June 2014 in “PLOS ONE” This study found that men with persistent sexual side effects after using finasteride for androgenetic alopecia had higher androgen receptor expression in certain tissues compared to those who never used the drug.
81 citations
,
June 2014 in “American Journal of Men's Health” This study highlights that adverse effects from finasteride may persist in men after discontinuation, indicating a potential "post-finasteride syndrome.
112 citations
,
July 2012 in “The Journal of Sexual Medicine” In this study, 96% of men with persistent sexual side effects from finasteride reported continued dysfunction after discontinuation, suggesting these effects may endure long-term.
223 citations
,
December 2010 in “The Journal of Sexual Medicine” This review discusses persistent adverse effects of 5α‐reductase inhibitors, like diminished libido and erectile dysfunction, in some patients and highlights the need for patient discussions before therapy, especially for androgenetic alopecia.
225 citations
,
July 2007 in “The Journal of Sexual Medicine” In this study, patients informed about finasteride's potential sexual side effects reported a significantly higher occurrence of these side effects, suggesting a nocebo effect.
408 citations
,
May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study found that dutasteride more effectively reduced serum dihydrotestosterone levels than finasteride in patients with benign prostatic hyperplasia.