TLDR Tamsulosin increases the risk of floppy iris during eye surgery.
This study evaluated the impact of tamsulosin, finasteride, and lorazepam on intraoperative iris behavior during phacoemulsification in 31 rabbits. The results indicated that tamsulosin (OR = 8.33), finasteride (OR = 11.6), and lorazepam (OR = 7.5) significantly increased the risk of intraoperative floppy iris syndrome (IFIS) compared to the control group. These findings suggest that these medications can alter iris behavior during cataract surgery, potentially leading to complications, and highlight the importance of preoperative documentation of these medications.
May 2022 in “International Journal of Trichology” 
28 citations,
February 2020 in “Clinical Ophthalmology” Certain medications and patient factors increase the risk of Intraoperative Floppy Iris Syndrome during cataract surgery, but with careful planning and technique adjustments, complications can be minimized.
22 citations,
March 2018 in “International Ophthalmology” Taking tamsulosin or finasteride and being older increase the risk of floppy iris during cataract surgery.
35 citations,
May 2020 in “Frontiers in Pharmacology” Different drugs for prostate-related urinary symptoms work but have various side effects, and treatment should be tailored to the individual.
May 2022 in “International Journal of Trichology” 5 citations,
December 2018 in “The Journal of clinical psychiatry/The journal of clinical psychiatry” Tamsulosin may slightly increase dementia risk compared to other treatments for enlarged prostate.
November 2012 in “Endocrine Practice” Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.
44 citations,
July 2012 in “Endocrine Practice” We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.
