Clinical Risk Factors Associated with Intraoperative Floppy Iris Syndrome: A Prospective Study

In a prospective study involving 319 patients undergoing cataract phacoemulsification, researchers identified an incidence of intraoperative floppy iris syndrome (IFIS) of 9.09%. The study concluded that the use of tamsulosin and finasteride, as well as increasing age, were significant risk factors for IFIS. Tamsulosin use was associated with a 5.78 times greater chance of developing IFIS, while finasteride use had an adjusted odds ratio of 7.64. No significant association was found between IFIS and doxazosin use, diabetes mellitus, glaucoma, pseudoexfoliation syndrome, or hypertension. The study also noted that IFIS prevalence increased with age, with an adjusted odds ratio of 1.09 for each additional year. Gender was not a significant factor in multivariate analysis. The study's limitations included a small number of cases, which restricted the analysis to three variables. The findings suggest that the risk of IFIS should be considered when prescribing tamsulosin and finasteride, and highlight the need for further research on IFIS causes, particularly in women not taking alpha1-adrenergic receptor antagonists.