TLDR Three natural compounds from Ghanaian plants may help treat BPH and alopecia.
The study utilized in silico techniques to screen 250 natural products from eight ethno-pharmacological plants in Ghana for potential inhibitors of 5alpha reductase 2 (5aR2), relevant for treating conditions like benign prostatic hyperplasia (BPH) and alopecia. Out of 254 compounds, three showed binding energies lower than testosterone and comparable to finasteride. Molecular docking and dynamics simulations identified Leu224 as critical for ligand binding. The selected compounds demonstrated good pharmacodynamics, low toxicity, and potential for treating BPH, alopecia, and other conditions, warranting further experimental validation.
July 2023 in “Dermatology and Therapy” 5-Alpha Reductase Inhibitors are effective for male hair loss and some skin conditions, but their effectiveness in women and safety concerns require careful use.
10 citations
,
March 2023 in “Journal of Chemistry” New compounds show promise for treating benign prostate hyperplasia with fewer side effects.
3 citations
,
January 2022 in “Precision medicine and clinical omics” Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.
14 citations
,
February 2018 in “Psychoneuroendocrinology” Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.
33 citations
,
May 2013 in “Andrologia” Some herbs show promise as antiandrogenic agents.
4 citations
,
July 2015 in “Veterinary Dermatology” Two types of 5α-reductase are in dog skin, which might make dutasteride better than finasteride for treating dog hair loss.
November 2023 in “Research Square (Research Square)” Finasteride affects the male rat brain by reducing certain protein activation, but these effects may reverse after stopping the drug.
