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This study found that phenyl-imidazole sulfonamide derivatives, particularly ISCK03, inhibited c-kit signaling and promoted depigmentation in various experimental settings, suggesting potential use as skin-whitening agents.

This study found that the DPP-4 inhibitor linagliptin slowed the progression of premature aging characteristics in klotho-/- mice, including improved body weight, cognitive function, and hair retention.

A specific gene mutation causes sparse, brittle hair in a family.

This study identified a missense mutation in the rat Desmoglein 4 gene, causing abnormal hair shaft development in lanceolate hair mutant rats by disrupting a critical calcium binding site.

This study describes a genetic mutation in the desmoglein 4 gene linked to localized autosomal recessive hypotrichosis in Pakistani families, showing similarities to animal models with similar hair loss conditions.

In this study, researchers created a new molecular salt from minoxidil and 2,4-dihydroxybenzoic acid, finding it superior to raw minoxidil for promoting hair growth in a mouse model, suggesting it may be a promising candidate for treating hair loss.

In this study on mice with severe thermal skin burns, researchers found that administering 4-aminopyridine (4-AP) helped reduce inflammation and apoptosis, promoted angiogenesis, and accelerated wound healing by enhancing specific cellular behaviors and signaling pathways.

The study found that growing dermal papilla cells in 3D spheroids enhances their activity with hair growth-promoting agents, such as minoxidil and TCQA, compared to traditional 2D cultures.

3D spheroid cells effectively test hair growth compounds like Minoxidil.

This study found that human hair follicle dermal papilla cells grown in a 3D model influenced hair growth and immune pathways more effectively than those grown in a 2D culture.

This study found that thymosin β4 is highly expressed in multiple human tissues and may play a role in organ function and angiogenesis through co-localization with VEGF.

This study found that minoxidil prevents long-term serotonergic toxicity induced by MDMA in rats, primarily by opening mitochondrial KATP channels and involving Akt and MAP kinases in its neuroprotective mechanism.

In this study on adult-onset, whole body Spry1/2/4 triple knockout mice, researchers observed endocrine abnormalities and no increased tumor incidence, despite similar food intake and motor function.

The researchers reported that thymosin beta 4 promotes hair growth in various rat and mice models by influencing follicle stem cell growth, migration, and differentiation.

This study identifies KLK14 as a significant factor contributing to hair defects and skin inflammation in a mouse model of Netherton syndrome.

The researchers reported that topical tofacitinib in mice increased hair follicles in the growth phase and boosted noggin and BMP4 mRNA expressions, compared to a vehicle and minoxidil.

Minoxidil 5% solution quickly improves hair growth and density with minimal side effects.

This study found that using minoxidil 2% as a mesotherapy injection showed more significant improvement in treating androgenetic alopecia in female patients than topical application.

Hyaluronic acid microneedles help deliver minoxidil derivatives effectively for hair regrowth.

In this study, researchers identified the miR-22-3p/CLIC4 signaling pathway as a key regulator in hair follicle miniaturization among androgenetic alopecia models, suggesting that targeting CLIC4-mediated sonic hedgehog pathway disruption may offer new therapeutic strategies for AGA treatment.

This study found that mice deficient in ceramide synthase 4 showed altered sebum composition and progressive hair loss due to obstructed hair canals.

This study suggests that impaired VDR signaling in mice leads to dysregulated Ddit4 expression, impacting hair cycle progression and wound healing.

This study found that neurotrophin-4 regulates Cav3.2 T-current expression in D-hair neurons via TrkB receptor activation, highlighting its role in mechanosensitive function.

This study found that maternal consumption of a western diet in mice led to toxic milk production, causing inflammation and alopecia in nursing neonates due to Toll-like-receptor activation.

In this study, long-term use of finasteride did not negatively impact bone mineral density in men with benign prostatic hyperplasia over a 4-year period.

This study found that fermented red ginseng marc alleviated atopic dermatitis-like symptoms in mice, demonstrating antioxidant and anti-inflammatory effects similar to those of dexamethasone.

This study found that maternal hephaestin knockout in mice leads to neonatal hair loss, likely due to low iron levels in the mother's milk.

This review discusses potential roles of zinc and copper in hair loss conditions like AA and TE, hypothesizing zinc's key role but noting that copper's effects need further investigation; it reports no new clinical findings.

This study reports that long-term use of finasteride does not affect bone mineral density in men with benign prostatic hyperplasia over a four-year period.

This study found that over-expression of thymosin beta-4 in transgenic mice accelerated wound healing and hair growth, but did not affect tumor progression despite stimulating tumor metastasis.