March 2025 in “Research Square (Research Square)” This study explored the potential of the lysate and lipoteichoic acid from Lactiplantibacillus plantarum APsulloc 331261 to improve scalp seborrheic dermatitis by modulating inflammatory and lipogenesis pathways in vitro, suggesting potential as a natural treatment option.
In this study, researchers identified an elite germplasm of the medicinal plant Eclipta alba, known for its liver disease benefits, with higher growth, yield, and wedelolactone content, suitable for large-scale cultivation to reduce strain on wild populations.
December 2024 in “Research Square (Research Square)” In this phase I/II clinical trial, placenta-derived mesenchymal stem cell exosome therapy significantly improved hair density and diameter, and reduced hair loss in patients with androgenetic alopecia, though further large-scale studies are needed to confirm these results and investigate the underlying molecular mechanisms.
November 2024 in “Research Square (Research Square)” This study found that lipid supplementation can enhance hair growth by promoting trichogenic gene expression and proliferation of human dermal papilla cells, suggesting lipids as a potential therapeutic target for treating hair loss through HIF-1 signaling pathways.
November 2024 in “Research Square (Research Square)” This study reported that Moracin M, a compound from the Moraceae family, significantly promoted hair growth and vascular regeneration by enhancing cell proliferation and Wnt signaling activation in laboratory settings, suggesting it may offer a promising alternative to existing hair growth treatments like minoxidil.
This study found that γδTregs can prevent and treat alopecia areata in a mouse model with human scalp transplants, suggesting potential for cell-based therapies in autoimmune diseases like alopecia.
This study found that new methods for isolating human dermal papilla cells were more efficient than traditional methods, maintaining higher levels of specific markers and improving the cells' research potential.
This study investigated the phytochemicals in Phyla nodiflora leaf extracts and identified n-Hexadecanoic acid, stigmasterol, and beta-sitosterol as promising drug candidates for diabetes, alopecia, cancer, and anti-diuresis, advocating further research into these compounds.
This study reports that in a rat model of myocardial infarction, Zn-Cu ion sequential therapy improved cardiac function and cardiomyocyte metabolic activity by precisely regulating ion concentrations and maintaining elevated levels of the Per2 protein, important for cellular repair.
In this case report, a 25-year-old female with Mixed Connective Tissue Disease presented unusual symptoms in a specific geographical region, prompting clinicians to approach diagnosis and management with caution due to potential severe complications such as pulmonary hypertension and renal crisis.
September 2024 in “Research Square (Research Square)” This study observed that 65.6% of acne patients also had PCOS, with these individuals showing more severe acne, higher testosterone levels, and greater prevalence of hirsutism and androgenic alopecia compared to those with isolated acne.
September 2024 in “Research Square (Research Square)” This study found that bi-weekly 1550nm low-level laser therapy significantly improved hair loss conditions and scalp health in participants, suggesting its potential as an effective non-invasive treatment option.
August 2024 in “Research Square (Research Square)” This study found that women taking 5α-reductase inhibitors (5aRI) for alopecia had a lower risk of breast cancer compared to those not using these medications, with no increased risk of developing ovarian or endometrial cancer.
July 2024 in “Research Square”
This study identified four genes related to alopecia areata: GIMAP6 and ALOX15 as risk factors, and GALNT6 and HEG1 as protective factors, noting significant validation differences in GALNT6 and HEG1.
July 2024 in “Research Square (Research Square)” In this study, researchers identified that certain inflammatory cytokines, including osteoprotegerin and leukemia inhibitory factor, are inversely associated with hypertrophic scar risk, whereas others like CDCP1, GDNF, and PD-L1 show a positive association, suggesting potential pathways for intervention in scar formation.
This study reported that Sintilimab combined with chemotherapy may improve outcomes in advanced NSCLC patients but carries a higher risk of certain side effects, including hypothyroidism.
July 2024 in “Research Square (Research Square)” In this study, ATP-sensitive potassium channel openers, diazoxide and minoxidil, reduced scratching in cholestatic mice, suggesting these channels may play a role in cholestatic itch, while the channel blocker glibenclamide increased scratching behavior.
July 2024 in “Research Square (Research Square)” This study investigated the expression of genes related to hair follicle aging in men with androgenetic alopecia, finding decreased levels of SIRT3 and SIRT7 and increased levels of NFATC1 and PDL-1, suggesting these genes' involvement in the condition's pathogenesis.
June 2024 in “Research Square (Research Square)” In this study, researchers identified nine FDA-approved drugs that activate the Wnt signaling pathway, with Aminoacridine, especially when combined with Minoxidil, showing promising effects on hair and nail growth in mice, suggesting potential treatments for hair and nail loss pending further clinical trials.
June 2024 in “Research Square (Research Square)” This study demonstrated that in mice, the absence of Jagged-1 expression in skin-resident regulatory T cells significantly delays wound healing by reducing the accumulation of neutrophils, highlighting the role of Jagged-1 in coordinating immune cell recruitment during injury.
June 2024 in “Research Square (Research Square)” This study found that among patients with systemic lupus erythematosus, the absence of skin rash and low levels of complement C3 were significant risk factors for developing lupus nephritis, with their combination demonstrating good predictive diagnostic value.
June 2024 in “Research Square (Research Square)” In this cross-sectional study, researchers observed that individuals with early-onset androgenetic alopecia showed significant differences in hair growth parameters and metabolic factors compared to those with normal-onset AGA, suggesting a potential association with metabolic syndrome, though more research is needed to clarify this relationship.
June 2024 in “Research Square (Research Square)” This study observed that combining botulinum toxin type A with Minoxidil significantly promoted hair growth, improved quality of life, and enhanced patient satisfaction in male androgenetic alopecia patients at 4 and 6 months, with no adverse effects compared to using Minoxidil alone.
June 2024 in “Research Square (Research Square)” This study found that among young women in West Bengal, India, co-occurring PCOS and related conditions like estrogen resistance and leptin receptor insufficiency are common, with notable genetic variations identified, including impairments in leptin signaling and insulin resistance.
In this observational study, researchers found that post-COVID-19 patients with telogen effluvium experienced varying hair loss and quality of life impacts, but no clear link was observed between this hair loss and vitamin D levels or quality of life.
June 2024 in “Research Square (Research Square)” This study identified a network of interactions between miRNAs and mRNAs that involve key signaling pathways, suggesting new insights into the mechanisms behind androgenetic alopecia.
June 2024 in “Research Square (Research Square)” This case report documented a 32-year-old man's acute pancreatitis following an overdose of finasteride, highlighting the potential for rare but severe side effects from the drug in overdose situations, and suggesting a need for further research into its safety.
June 2024 in “Research Square (Research Square)” This study found that women experiencing hair loss post-COVID-19 showed significantly decreased serum copper levels, suggesting potential further research into copper supplementation for preventing and treating post-COVID-19 alopecia.
May 2024 in “Research Square (Research Square)” In this study, impaired sexual function among Iranian women with infertility was linked to higher sexual distress, especially when comorbid PCOS was present, affecting the relationship between sexual pain and distress.