The Possible Involvement of KATP Channels in Cholestatic Pruritus in Mice

    July 2024 in “ Research Square (Research Square) ”
    Arya Afrooghe, Maryam Shayan, Nazgol‐Sadat Haddadi, Asma Rashki, Shahabaddin Solaimanian, Maryam Shokrian Zeini, Ahmad Reza Dehpour
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    TLDR KATP channels may help reduce itching in liver disease.
    The study investigates the role of ATP-sensitive potassium (K<sub>ATP</sub>) channels in cholestatic pruritus in mice, a condition that significantly affects quality of life. The research found that K<sub>ATP</sub> channel openers, diazoxide and minoxidil, reduced scratching behavior in mice with bile duct ligation-induced cholestasis, while the K<sub>ATP</sub> channel blocker glibenclamide increased scratching. Additionally, a sub-effective dose of glibenclamide reversed the anti-pruritic effects of the channel openers. The study also noted an increase in the expression of the Kcnj11 gene in affected mice. These findings suggest that K<sub>ATP</sub> channels may play a role in cholestatic itch, warranting further research to explore this connection.
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