Pharmacological Evidence for the Involvement of Adenosine Triphosphate Sensitive Potassium Channels in Chloroquine-Induced Itch in Mice

June 2017 in “ Pharmacological Reports ”

Sattar Ostadhadi, Arash Foroutan, Nazgol‐Sadat Haddadi, Abbas Norouzi-Javidan, Majid Momeny, Ghazaleh Zarrinrad, Seyed H. Ghaffari, Ahmad‐Reza Dehpour

ATP-sensitive potassium channels chloroquine intradermal injection scratching behavior KATP channel openers diazoxide minoxidil KATP channel blocker glibenclamide qRT-PCR Kcnj8 gene

TLDR ATP-sensitive potassium channels play a role in chloroquine-induced itch in mice.

The study investigated the role of ATP-sensitive potassium (KATP) channels in chloroquine (CQ)-induced itch in mice. Intradermal injection of CQ caused scratching behavior, which was significantly reduced by pretreatment with KATP channel openers diazoxide (DZX) and minoxidil (MIN). Conversely, the KATP channel blocker glibenclamide (GLI) reversed the anti-pruritic effects of DZX and MIN. Additionally, qRT-PCR analysis showed decreased expression of the Kcnj8 gene after CQ injection. These findings suggested that KATP channels were involved in CQ-induced itch, indicating a potential link between cellular metabolic state and itch.

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