Pharmacological Evidence for the Involvement of Adenosine Triphosphate Sensitive Potassium Channels in Chloroquine-Induced Itch in Mice

    June 2017 in “ Pharmacological Reports
    Sattar Ostadhadi, Arash Foroutan, Nazgol‐Sadat Haddadi, Abbas Norouzi-Javidan, Majid Momeny, Ghazaleh Zarrinrad, Seyed H. Ghaffari, Ahmad‐Reza Dehpour
    TLDR ATP-sensitive potassium channels play a role in chloroquine-induced itch in mice.
    The study investigated the role of ATP-sensitive potassium (KATP) channels in chloroquine (CQ)-induced itch in mice. Intradermal injection of CQ caused scratching behavior, which was significantly reduced by pretreatment with KATP channel openers diazoxide (DZX) and minoxidil (MIN). Conversely, the KATP channel blocker glibenclamide (GLI) reversed the anti-pruritic effects of DZX and MIN. Additionally, qRT-PCR analysis showed decreased expression of the Kcnj8 gene after CQ injection. These findings suggested that KATP channels were involved in CQ-induced itch, indicating a potential link between cellular metabolic state and itch.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 56 results

      community Nice product I discovered, thought I would share.

      in Treatment  456 upvotes 4 months ago
      A product that makes hair look thicker and healthier without promoting regrowth. Discussions include treatments like minoxidil, finasteride, red light therapy, and a serum with caffeine and peptides, with mixed effectiveness opinions.
      Saw palmetto + minoxidil + nizoral + dermaroller

      community Saw palmetto + minoxidil + nizoral + dermaroller

      in Journals / Progress Pictures  317 upvotes 3 months ago
      The user replaced finasteride with saw palmetto due to availability issues and experienced side effects, leading to adjustments in their regimen. They use saw palmetto, minoxidil, Nizoral, and a dermaroller, reporting reduced side effects and some benefits, with hair fall ranging from 5 to 20 hairs daily.

      community 5 years on finasteride only: age 21 to 26.

      in Progress Pictures  769 upvotes 1 month ago
      A user shared their five-year experience with finasteride for hair loss, noting positive results and no side effects. The discussion included debates on potential side effects like erectile dysfunction and the treatment's effectiveness.

    Similar Research

    5 / 1000+ results