Lactiplantibacillus Plantarum Lysate From Green Tea Leaves Alleviates Effects of Malassezia Restricta on Human Scalp Cells

March 2025 in “ Research Square (Research Square) ”

Kil-Sun Myoung, Seunghyun Shin, Suna Kim, Heung Soo Baek, Hyoung-June Kim, Jae Sung Hwang

Lactiplantibacillus plantarum lysate green tea leaves scalp seborrheic dermatitis Malassezia restricta tight junctions inflammatory cytokines scalp keratinocytes sebocytes lipoteichoic acid outer root sheath cell dermal papilla cell L. plantarum lysate green tea SSD MR LTA

TLDR Lactiplantibacillus plantarum lysate from green tea may help treat scalp seborrheic dermatitis.

The study explores the potential of Lactiplantibacillus plantarum lysate, isolated from green tea leaves, as a natural treatment for scalp seborrheic dermatitis (SSD), a condition linked to Malassezia restricta (MR). While the lysate did not directly affect MR growth, it improved gene expression related to tight junctions and inflammatory cytokines in scalp keratinocytes and reduced lipid production in sebocytes induced by heat-killed MR. Additionally, the lysate and its lipoteichoic acid (LTA) component protected outer root sheath cell viability and promoted dermal papilla cell growth. These findings suggest that APsulloc’s cell wall components could be effective in managing SSD in vitro.

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