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    Glossary Outer Root Sheath

    layer of cells surrounding and supporting the hair follicle

    The Outer Root Sheath (ORS) is a layer of cells that surrounds the hair follicle, providing structural support and playing a crucial role in the growth and cycling of hair. It extends from the epidermis down to the hair bulb and is involved in the regeneration of the hair follicle after shedding.

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    1. Pitx2, a β-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro Journal of dermatological science · 2009 · 51 citations
    2. The chemotactic effect of a dermal papilla cell-derived factor on outer root sheath cells Journal of Dermatological Science · 2001 · 47 citations
    3. Wnt/β‐catenin and ERK pathway activation: A possible mechanism of photobiomodulation therapy with light‐emitting diodes that regulate the proliferation of human outer root sheath cells Lasers in Surgery and Medicine · 2017 · 43 citations
    4. Manipulation of outer root sheath cell survival perturbs the hair-growth cycle The EMBO Journal · 1999 · 37 citations
    5. VEGF165 modulates proliferation, adhesion, migration and differentiation of cultured human outer root sheath cells from central hair follicle epithelium through VEGFR-2 activation in vitro Journal of Dermatological Science · 2013 · 35 citations
    6. Organotypic culture of outer root sheath cells from human hair follicles using a new culture device In Vitro Cellular & Developmental Biology - Plant · 1987 · 35 citations
    7. Effect of thioredoxin reductase 1 on glucocorticoid receptor activity in human outer root sheath cells Biochemical and Biophysical Research Communications · 2007 · 34 citations
    8. VEGF upregulates VEGF receptor-2 on human outer root sheath cells and stimulates proliferation through ERK pathway Molecular Biology Reports · 2012 · 23 citations
    9. Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles Scientific reports · 2017 · 22 citations
    10. miR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells Frontiers in cell and developmental biology · 2020 · 18 citations
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