TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling

August 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”

Luyang Xiong, Irina Zhevlakova, Xiaoxia Z. West, Detao Gao, Rakhylia Murtazina, Anthony Horak, J. Mark Brown, Iuliia Molokotina, Eugene A. Podrez, Tatiana V. Byzova

TLR2 Toll-like receptor 2 hair follicle stem cells HFSCs BMP signaling carboxyethylpyrrole CEP polyunsaturated fatty acids hair regeneration innate immunity hair follicle cycle hair follicle health hair loss PUFAs

TLDR TLR2, a component in hair follicle stem cells, is crucial for healthy hair growth and regeneration, and its decrease can lead to hair loss.

The study "TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling" reveals that the maintenance and regeneration of hair follicles depend on TLR2 (Toll-like receptor 2) in hair follicle stem cells (HFSCs). TLR2 is expressed in a cycle-dependent manner in healthy hair follicles and regulates HFSC activation by counteracting inhibitory BMP signaling. Aging and obesity are associated with a decrease in both TLR2 and its endogenous ligand carboxyethylpyrrole (CEP), a metabolite of polyunsaturated fatty acids, which may lead to diminished hair growth. However, administering CEP can stimulate hair regeneration through a TLR2-dependent mechanism. This research establishes a new link between TLR2-mediated innate immunity and HFSC activation, which is crucial for hair follicle health and preventing hair loss.

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research TLR2 Regulates Hair Follicle Cycle and Regeneration via BMP Signaling

August 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

TLR2, a component in hair follicle stem cells, is crucial for healthy hair growth and regeneration, and its decrease can lead to hair loss.