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This study found that 3D-cultured dermal papilla cells more accurately mimic in vivo conditions compared to 2D cultures, enhancing our understanding of molecular mechanisms in androgen-induced alopecia.

In this study, researchers developed a novel 3D bio-printed skin scaffold using exosomes from liver cells, which enhanced wound healing by promoting cell growth, angiogenesis, and reducing inflammation in large skin injuries, suggesting potential applications in treating chronic skin conditions.

This review highlights how organoid technology is transforming precision medicine by summarizing its development and applications in modeling diseases, testing drug efficacy, and tailoring patient-specific treatments, despite current challenges in standardization and ethical considerations.

This review discusses recent advancements in the study and application of epidermal stem cells for wound healing and tissue engineering, without presenting new experimental findings.

This review summarizes advancements in biomedical engineering for hair follicle regeneration, highlighting strategies like cell transplantation and tissue engineering to reconstruct hair follicles, and discusses both their technical limitations and potential future innovations in regenerative medicine.

The study investigated immune cell patterns around the hair follicle infundibulum in androgenetic alopecia, revealing significant differences in immune signatures between patients with AGA and control donors, specifically noting an enrichment of CD4 cells in the patient group.

This study successfully developed 3D hair follicle organoids from neonatal mouse epidermal and dermal cells, showing structural and molecular resemblance to native anagen hair follicles.

This study reviews advancements in hair follicle regeneration, discussing the benefits and limitations of methods such as organ germ assembling, stem cell induction, and bioprinting, while highlighting the challenges of replicating embryonic signals and finding suitable cell sources for clinical applications.

This review discusses various tissue engineering approaches for hair follicle regeneration and biomaterials used, emphasizing its potential despite current clinical challenges.

This review discusses strategies to enhance mesenchymal stem cell therapy effectiveness but reports no new clinical results; it highlights the need for improved consistency and efficacy in MSC-based treatments.

This study found that lysine carboxymethyl cysteinate helps protect the epidermis from UVB-induced damage by activating autophagy and restoring cornification processes in a skin model.

Confocal Laser Scanning Microscopy (CLSM) is a useful tool for studying how drugs interact with skin and diagnosing skin disorders, despite some limitations.

This study systematically reviews the development and applications of drug-loaded nanofiber scaffolds in wound healing, highlighting challenges such as maintaining drug activity and achieving controlled release, while summarizing preparation methods and describing advanced drug delivery schemes.

This study found that TGF-β2 may enhance collagen expression and spheroid formation in human dermal papilla cells, which could improve their hair inductivity and maintenance.

This study reviewed various methods and techniques aimed at overcoming limitations in culturing human hair follicles, specifically focusing on restoring the inductivity of hair follicle cells for successful hair regeneration.

This study found that altering cell culture conditions to form three-dimensional papilla spheroids can restore the ability of human dermal papilla cells to induce hair growth in adult skin.

This study found that using 3D dermal papilla spheroid models enhances extracellular matrix production and hair follicle marker expression, providing insights into hair follicle biology and potential for drug screening.

This study found that mammary resident macrophages regulate mammary epithelium cell division and development, with implications for maintaining mammary stem cell activity and homeostasis.

This study found that super-enhancers are essential for hair follicle stem cell identity, lineage commitment, and plasticity in mice, with SOX9 being a key regulator of these chromatin dynamics.

This study demonstrated that enhancing human skin constructs with hair follicles through engineered cell organization and vascularization improved hair growth in immunodeficient mice, suggesting potential advances for treating alopecia and chronic wounds.

This study reported that a three-dimensional hydrogel culture system supports the growth and maintenance of distinct dermal papilla cell types, crucial for skin reconstitution assays in neonatal mice.

This review highlighted that in an in vitro setting, 3D spheroid cultures of fish cells offer a promising alternative to traditional monolayer cultures, potentially advancing research in eco-toxicology, immunology, drug screening, and more by better mimicking in vivo conditions.

This study found that platelet-rich plasma might support brain health by enhancing glial cell function and modulating immune responses in inflammation, indicating potential as a treatment for brain disorders.

This review highlights recent advancements in microfluidics for 3D tissue model generation and discusses its applications in tissue engineering and high-throughput drug screening without reporting new experimental results.

In this study, researchers found that wound healing in mouse skin recruits diverse fibroblasts, including myeloid-derived cells, which contribute to regenerating adipocytes.

This study found that 3D-printed polyamine-modified hydrogels facilitate M2 macrophage polarization and exosome secretion, enhancing skin cell compatibility and promoting wound healing and hair follicle induction in an animal model through specific signaling pathways, suggesting potential for skin disorder therapies.

This study found that the culture conditions, not species-specific differences, determined whether sika deer dermal papilla cells adopted a 3D spheroidal or 2D monolayer growth pattern, influencing their hair-inducing ability.

This study found that a mesenchymal stromal cell-derived regenerative extracellular matrix (rECM) significantly accelerated wound closure and improved healing in diabetic mice, also enhancing nerve and blood vessel formation compared to controls.

This review reports that 3D skin bioprinting has made significant progress towards clinical application, particularly in wound healing and disease modeling, but further work on vascularization and bioink standardization remains crucial.

This study found that anisotropic osmolyte solutions may improve hair follicle turnover and condition in both in vitro and in silico models, as well as in human volunteers with hair disorders.