Immunomodulatory Effects of Platelet-Rich Plasma on Neuroinflammation: Insights from BV2 Glial Cells Stimulated with Heat-Killed Escherichia Coli

This study investigates the effects of platelet-rich plasma (PRP) on BV2 glial cells to understand its potential neuroprotective properties. PRP was found to enhance glial cell viability and proliferation in a dose-dependent manner, increase the expression of the anti-apoptotic gene BCL-2, and decrease levels of Caspase-3 and BAX. It modulated cytokine profiles by reducing TNF-α and upregulating IL-10, while increasing IL-1β expression. PRP mitigated inflammatory damage and preserved glial integrity, particularly under sterile conditions, and reduced oxidative stress induced by heat-killed E. coli without affecting phagocytic activity. These findings suggest that PRP could help control brain inflammation from injury or infection, offering potential as a treatment for brain disorders.