Immunomodulatory Effects of Platelet-Rich Plasma on Neuroinflammation: Insights from BV2 Glial Cells Stimulated with Heat-Killed Escherichia Coli
November 2025
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Studysummary This study found that platelet-rich plasma might support brain health by enhancing glial cell function and modulating immune responses in inflammation, indicating potential as a treatment for brain disorders.
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This study investigates the effects of platelet-rich plasma (PRP) on BV2 glial cells to understand its potential neuroprotective properties. PRP was found to enhance glial cell viability and proliferation in a dose-dependent manner, increase the expression of the anti-apoptotic gene BCL-2, and decrease levels of Caspase-3 and BAX. It modulated cytokine profiles by reducing TNF-α and upregulating IL-10, while increasing IL-1β expression. PRP mitigated inflammatory damage and preserved glial integrity, particularly under sterile conditions, and reduced oxidative stress induced by heat-killed E. coli without affecting phagocytic activity. These findings suggest that PRP could help control brain inflammation from injury or infection, offering potential as a treatment for brain disorders.
