The Role of Epigenetics in the Pathogenesis of Cutaneous Diseases: A Comprehensive Review

    August 2026 in “ International Journal of Research in Medical Sciences ”
    Ghadah Alhetheli
    Studysummary This article reviews how epigenetic modifications, particularly DNA methylation, histone modification, and non-coding RNA pathways, affect the development of skin diseases, suggesting potential for personalized treatments that target these changes.
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    Research cited in this study 18

    1. Research Progress on the Synergistic Role of Gut Microbiota and Exosomal miRNAs in the Treatment of Androgenetic Alopecia Current Topics in Medicinal Chemistry · 2026
    2. ROS-Responsive Hydrogel-Delivered miR-665 Targets STAT3 to Alleviate Inflammation and Promote Hair Follicle Regeneration in Alopecia Areata Journal of Nanobiotechnology · 2026
    3. Molecular Crosstalk Between lncRNA H19, miR-29a, and JAK2/STAT3 Signaling in Alopecia Areata: A Preliminary Study Cytokine · 2026
    4. Exosomes in Trichology: A Literature Review JPRAS Open · 2025
    5. Circulating MicroRNA Signatures in Severe Alopecia Areata: Diagnostic Discrimination, Pathway Analysis, and Therapeutic Implications Preprints.org · 2025
    6. UTX (KDM6A) Promotes Differentiation Noncatalytically in Somatic Self-Renewing Epithelia Proceedings of the National Academy of Sciences · 2025
    7. LncRNA NEAT1 and miRNA 101 as Potential Diagnostic Biomarkers in Patients with Alopecia Areata Non-coding RNA Research · 2024
    8. The Role of hsa-miR-193a-5p as an Important Factor for Control of Inositol in Alopecia Areata Skin Research and Technology · 2024
    9. LncRNA RP11-818O24.3 Promotes Hair Follicle Recovery via FGF2-PI3K/Akt Signal Pathway Cytotechnology · 2024
    10. Retinoic Acid Drives Hair Follicle Stem Cell Activation via Wnt/Beta-Catenin Signalling in Androgenetic Alopecia JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2024
    11. DNA Methylation Of MicroRNA-365-1 Induces Apoptosis Of Hair Follicle Stem Cells By Targeting DAP3 Non-coding RNA Research · 2024
    12. MiR-200c-3p as a Novel Genetic Marker and Therapeutic Tool for Alopecia Areata Skin Research and Technology · 2024
    13. MiR-199a-3p Regulates the PTPRF/β-Catenin Axis in Hair Follicle Development: Insights into the Pathogenic Mechanism of Alopecia Areata International journal of molecular sciences · 2023
    14. SIRT1 Downregulation Provokes Immune-Inflammatory Responses in Hair Follicle Outer Root Sheath Cells and May Contribute to Development of Alopecia Areata Journal of Dermatological Science · 2023
    15. Genome-Wide Meta-Analysis Identifies Novel Loci Conferring Risk of Acne Vulgaris European Journal of Human Genetics · 2023
    16. An Integrative Analysis of the LncRNA-MiRNA-mRNA Competitive Endogenous RNA Network Reveals Potential Mechanisms in the Murine Hair Follicle Cycle Frontiers in Genetics · 2022
    17. Comprehensive Analysis of LncRNA AC010789.1 Delays Androgenic Alopecia Progression by Targeting MicroRNA-21 and the Wnt/β-Catenin Signaling Pathway in Hair Follicle Stem Cells Frontiers in Genetics · 2022
    18. Histone Deacetylase 1 in Patients With Alopecia Areata and Acne Vulgaris: An Epigenetic Alteration Australasian Journal of Dermatology · 2022