The Role of hsa-miR-193a-5p as an Important Factor for Control of Inositol in Alopecia Areata

    June 2024 in “ Skin Research and Technology ”
    Ahmed Ibrahim AbdElneam, Mohammed Saleh Al‐Dhubaibi, Saleh Salem Bahaj, Ghada Farouk Mohammed, Lina M. Atef
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    TLDR hsa-miR-193a-5p may help diagnose and treat alopecia areata.
    The study identifies hsa-miR-193a-5p as significantly over-expressed in alopecia areata (AA) patients compared to healthy controls, suggesting its role in AA's onset or progression. With a sample size of 77 AA patients and 75 controls, the study found that hsa-miR-193a-5p impacts the IPPK gene, which is involved in the inositol phosphorylation and Phosphatidylinositol signaling pathways, crucial for hair growth. The findings highlight hsa-miR-193a-5p as a potential diagnostic and therapeutic target for AA, with future research needed to validate these results with larger sample sizes and lesional skin biopsies.
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