TLDR High CRP levels could indicate vitamin D deficiency in people with alopecia areata.
The study involved 82 patients with alopecia areata (AA) and 81 healthy controls, investigating the association between vitamin D and C-reactive protein (CRP) levels, and the influence of Vitamin D receptor (VDR) gene polymorphism CDX2 rs11568820. Results showed AA patients had higher CRP levels and lower vitamin D and VDR gene expression levels than healthy controls. CRP was found to be a highly accurate biomarker for diagnosing AA, with a sensitivity of 88.5% and a specificity of 87.6%. The CDX2 rs11568820 variant was also significantly associated with AA, with different genotypes showing varying levels of vitamin D and CRP. The study concluded that vitamin D deficiency could potentially disrupt the immune system, contributing to AA, and suggested testing CRP to evaluate disease activity and severity in AA.
2 citations,
June 2023 in “Skin Research and Technology” Yellow dots and short vellus hairs are the most common signs of Alopecia Areata (AA), and trichoscopy can help diagnose AA and track treatment progress.
4 citations,
April 2023 in “Autoimmunity reviews” High levels of IL6 and CRP, and low levels of vitamin D, might be indicators of alopecia areata.
3 citations,
October 2022 in “Journal of Cosmetic Dermatology” CAR is a useful marker for assessing alopecia areata severity.
144 citations,
July 2015 in “Clinical, Cosmetic and Investigational Dermatology” Alopecia areata is a common autoimmune disease affecting about 2% of people, causing significant disability and often associated with mental health issues and other autoimmune conditions.
105 citations,
March 2014 in “British journal of dermatology/British journal of dermatology, Supplement” Alopecia areata patients often have low vitamin D levels, suggesting they might benefit from vitamin D supplements.
185 citations,
December 2011 in “Molecular and cellular endocrinology” Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.
April 2019 in “International journal of research in dermatology” A child with rough nails also had hair loss and allergies.
