Genome-Wide Meta-Analysis Identifies Novel Loci Conferring Risk of Acne Vulgaris

    March 2023 in “ European Journal of Human Genetics ”
    Maris Teder‐Laving, Mart Kals, Anu Reigo … Külli Kingo
    Studysummary This study identified four new genetic loci associated with acne risk and highlighted key pathways involved in its genetic predisposition, potentially explaining 9.4% of acne's phenotypic variance.
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    Research cited in this study 11

    1. Aberrant Wnt Signaling Induces Comedo-Like Changes in the Murine Upper Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2021
    2. Gene Variants Associated With Acne Vulgaris Presentation and Severity: A Systematic Review and Meta-Analysis BMC Medical Genomics · 2021
    3. Homeostasis of the Sebaceous Gland and Mechanisms of Acne Pathogenesis British Journal of Dermatology · 2019
    4. What Does Acne Genetics Teach Us About Disease Pathogenesis? British Journal of Dermatology · 2019
    5. CAG Polymorphism in the Androgen Receptor Gene in Women May Be Associated with Nodulocystic Acne Postepy Dermatologii I Alergologii · 2019
    6. Genome-Wide Meta-Analysis Implicates Mediators of Hair Follicle Development and Morphogenesis in Risk for Severe Acne Nature Communications · 2018
    7. Beyond Acne: Current Aspects of Sebaceous Gland Biology and Function Reviews in Endocrine and Metabolic Disorders · 2016
    8. Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity Cell reports · 2016
    9. In Vivo Transcriptional Governance of Hair Follicle Stem Cells by Canonical Wnt Regulators Nature Cell Biology · 2014
    10. C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis Cell reports · 2013
    11. Wnt Signaling in Skin Development, Homeostasis, and Disease Cold Spring Harbor Perspectives in Biology · 2012

    Related research 1

    1. The First Broad Replication Study of SNPs and a Pilot Genome-Wide Association Study for Androgenetic Alopecia in Asian Populations Journal of Cosmetic Dermatology · 2022