The Hair Growth Effects of Wheat Bran

January 2013 in “ Korean Journal of Pharmacognosy ”

Jung-Il Kang, Hee Kyoung Kang, Eun-Sook Yoo, Young Sang Koh, Youngki Lee, Eunji Kim, 문정선, 임동술

wheat bran n-hexane fraction telogen-anagen transition vibrissa dermal papilla cells DPCs cyclin D1 cyclin E phospho-CDK2 phospho-pRB Wnt/β-catenin signaling pathway phospho(ser552)-β-catenin phospho(ser675)-β-catenin phospho(ser9)-GSK3β hair growth cell cycle proteins Wnt signaling

Studysummary Wheat bran can boost hair growth by affecting cell cycle proteins and signaling pathways.

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The study investigated the effects of wheat bran on hair growth, focusing on its impact on rat vibrissa follicles and C57BL/6 mice. Treatment with the n-hexane fraction of wheat bran significantly increased hair-fiber lengths and induced the telogen-anagen transition. The fraction also promoted the proliferation of immortalized vibrissa dermal papilla cells (DPCs) in a dose-dependent manner. Molecular analysis revealed that this proliferation was associated with increased levels of cell cycle proteins such as cyclin D1, cyclin E, phospho-CDK2, and phospho-pRB, as well as components of the Wnt/β-catenin signaling pathway, including phospho(ser552)-β-catenin, phospho(ser675)-β-catenin, and phospho(ser9)-GSK3β. These findings suggested that wheat bran could enhance hair growth by regulating cell cycle proteins and Wnt/β-catenin signaling in DPCs.

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