A Randomized Controlled Clinical Trial Protocol of Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles for the Treatment of Androgenetic Alopecia in Young Males

    January 2026 in “ The FASEB Journal ”
    Ruiyun Tian, Zhenjun Deng, Fuming Chen … Furong Li
    Studysummary This upcoming clinical trial at Shenzhen People's Hospital will explore the safety and efficacy of human umbilical cord mesenchymal stem cell-derived small extracellular vesicles as a treatment for androgenetic alopecia in young men, comparing them to minoxidil. Results are not reported yet.
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    Research cited in this study 20

    1. Phase I Clinical Trial: Evaluating the Efficacy, Safety, and Patient Satisfaction of Platelet-Rich Plasma Injections and Microneedling for Androgenetic Alopecia Treatment Journal of Cosmetic Dermatology · 2025
    2. Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Enhance Follicular Regeneration in Androgenetic Alopecia via Activation of Wnt/β-Catenin Pathway Stem Cell Research & Therapy · 2025
    3. Potential of Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Androgenetic Alopecia World Journal of Stem Cells · 2025
    4. Exploring the Dermatological Applications of Human Mesenchymal Stem Cell Secretome: A Comprehensive Review Stem Cell Research & Therapy · 2025
    5. A Pilot Randomized Controlled Trial Evaluating the Efficacy of an Exosome-Containing Plant Extract Formulation for Treating Male Alopecia Life · 2025
    6. Evaluating the Efficacy and Safety of Combined Microneedling Therapy Versus Topical Minoxidil in Androgenetic Alopecia: A Systematic Review and Meta-Analysis Archives of Dermatological Research · 2025
    7. Assessing the Safety of Topical Minoxidil Through Disproportionality Analysis of FAERS Reports Expert Opinion on Drug Safety · 2025
    8. Improvement of Androgenic Alopecia by Extracellular Vesicles Secreted from Hyaluronic Acid-Stimulated Induced Mesenchymal Stem Cells Stem Cell Research & Therapy · 2024
    9. Effectiveness of Exosome Treatment in Androgenetic Alopecia: Outcomes of a Prospective Study Aesthetic Plastic Surgery · 2024
    10. Clinical And Preclinical Approach In AGA Treatment: A Review Of Current And New Therapies In The Regenerative Field Stem Cell Research & Therapy · 2024
    11. 18-β-Glycyrrhetinic Acid Promotes Hair Growth by Stimulating the Proliferation of Dermal Papilla Cells and Outer Root Sheath Cells, and Extends the Anagen Phase by Inhibiting 5α-Reductase Biological and Pharmaceutical Bulletin · 2024
    12. Exosomes Derived From Umbilical Cord Mesenchymal Stem Cells Promote Hair Regrowth in Alopecia Areata Cell Biology International · 2023
    13. Psychosocial Impact of Androgenetic Alopecia on Men: A Systematic Review and Meta-Analysis Psychology, Health & Medicine · 2023
    14. Exosome Therapy in Hair Regeneration: A Literature Review of the Evidence, Challenges, and Future Opportunities Journal of cosmetic dermatology · 2022
    15. Efficacy and Safety of Topical Finasteride Spray Solution for Male Androgenetic Alopecia: A Phase III, Randomized, Controlled Clinical Trial Journal of The European Academy of Dermatology and Venereology · 2021
    16. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    17. Efficacy and Safety of Very-Low-Dose Oral Minoxidil 1.25 mg in Male Androgenetic Alopecia Journal of The American Academy of Dermatology · 2020
    18. Early-Onset Androgenetic Alopecia in China: A Descriptive Study of a Large Outpatient Cohort Journal of International Medical Research · 2020
    19. Prevalence of Androgenetic Alopecia in China: A Community-Based Study in Six Cities British Journal of Dermatology · 2010
    20. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007